Two Drosophila Neuropeptide Y-like Neurons Define a Reward Module for Transforming Appetitive Odor Representations to Motivation
| Autor: | Yan Zhang, Ping Shen, Yiwen Zhang, Yuhan Pu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Dopamine Neuropeptide F Appetite lcsh:Medicine Neuropeptide Biology Article Arousal 03 medical and health sciences 0302 clinical medicine medicine Animals Drosophila Proteins Neuropeptide Y lcsh:Science Motivation Multidisciplinary Dopaminergic Neurons Neuropeptides lcsh:R Dopaminergic Feeding Behavior Neuropeptide Y receptor Rhombencephalon Smell Drosophila melanogaster 030104 developmental biology Odor Larva Odorants lcsh:Q Neuroscience 030217 neurology & neurosurgery Drosophila larvae medicine.drug |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-30113-5 |
| Popis: | Neuropeptides, many of which are conserved among vertebrate and invertebrate animals, are implicated in the regulation of motivational states that selectively facilitate goal-directed behaviors. After a brief presentation of appetitive odors, Drosophila larvae display an impulsive-like feeding activity in readily accessible palatable food. This innate appetitive response may require coordinated signaling activities of dopamine (DA) and neuropeptide F (NPF; a fly homolog of neuropeptide Y). Here we provide anatomical and functional evidence, at single-cell resolution, that two NPF neurons define a reward module in the highest-order brain region for cognitive processing of food-related olfactory representations. First, laser lesioning of these NPF neurons abolished odor induction of appetitive arousal, while their genetic activation mimicked the behavioral effect of appetitive odors. Further, a circuit analysis shows that each of the two NPF neurons relays its signals to a subset of target neurons in the larval hindbrain-like region. Finally, the NPF neurons discriminatively responded to appetitive odor stimuli, and their odor responses were blocked by targeted lesioning of a pair of dopaminergic third-order olfactory neurons that appear to be presynaptic to the NPF neurons. Therefore, the two NPF neurons contribute to appetitive odor induction of impulsive-like feeding by selectively decoding DA-encoded ascending olfactory inputs and relaying NPF-encoded descending motivational outputs for behavioral execution. |
| Databáze: | OpenAIRE |
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