Receptor‐like kinases MDS1 and MDS2 promote SUMM2‐mediated immunity
| Autor: | Zhibin Zhang, Xionghui Zhong, Yanan Liu, Xin Li, Xingchuan Huang, Hainan Tian, Yuelin Zhang, Jiameng Lan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0301 basic medicine Arabidopsis Plant Immunity Autoimmunity Plant Science Immune receptor Protein Serine-Threonine Kinases Biology 01 natural sciences Biochemistry General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Suppression Genetic Immunity Phosphorylation Receptor Arabidopsis Proteins Kinase fungi biochemical phenomena metabolism and nutrition In vitro Cell biology 030104 developmental biology Mutation bacteria Carrier Proteins Function (biology) 010606 plant biology & botany |
| Zdroj: | Journal of Integrative Plant Biology. 63:277-282 |
| ISSN: | 1744-7909 1672-9072 |
| DOI: | 10.1111/jipb.12978 |
| Popis: | Disruption of the MEKK1-MKK1/MKK2-MPK4 kinase cascade leads to activation of immunity mediated by the nucleotide-binding leucine-rich repeat (NLR) immune receptor SUMM2, which monitors the phosphorylation status of CRCK3. Here we report that two receptor-like kinases (RLKs), MDS1, and MDS2, function redundantly to promote SUMM2-mediated immunity. Activation of SUMM2-mediated immunity is dependent on MDS1, and to a less extent on MDS2. MDS1 associates with CRCK3 in planta and can phosphorylate CRCK3 in vitro, suggesting that it may target CRCK3 to positively regulate SUMM2-mediated signaling. Our finding highlights a new defense mechanism where RLKs promote NLR-mediated immunity. |
| Databáze: | OpenAIRE |
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