Histologic comparison of direct pulp capping of rat molars with MTA and different concentrations of simvastatin gel
Autor: | Sara Saedi, Zohreh Ahangari, Fatemeh Mashhadiabbas, Saeed Reza Motamedian, Omid Dianat |
---|---|
Rok vydání: | 2018 |
Předmět: |
Male
0301 basic medicine Mineral trioxide aggregate Molar Simvastatin H&E stain Dental Pulp Capping Andrology 03 medical and health sciences 0302 clinical medicine stomatognathic system Maxilla polycyclic compounds Dentin medicine Animals Rats Wistar Aluminum Compounds General Dentistry Inflammation Chemistry Silicates nutritional and metabolic diseases Oxides 030206 dentistry Calcium Compounds Dentin Formation Pulp capping Drug Combinations 030104 developmental biology medicine.anatomical_structure Gels After treatment medicine.drug |
Zdroj: | Journal of Oral Science. 60:57-63 |
ISSN: | 1880-4926 1343-4934 |
Popis: | Previous in vitro studies have suggested that simvastatin can be used as a direct pulp capping material due to its ability to induce odontoblastic differentiation and angiogenesis. The aim of this animal study was to evaluate the pulpal response to mineral trioxide aggregate (MTA) and four concentrations of simvastatin/MTA in combination. The study was conducted in two stages using four different simvastatin concentrations and MTA as a capping material for rat maxillary molars. The grades of inflammation and continuity of dentin formation were evaluated in hematoxylin and eosin (HE)-stained samples. Dentin thickness was determined by histomorphometric analysis, and the data were subjected to statistical analysis. On day 3, mild inflammation was observed in all groups. On day 7, the simvastatin groups showed a slightly higher rate of chronic inflammation. Inflammation was not present on day 30. Discontinuous dentin was present in all methylcellulose (control) samples. Continuous dentin was formed in all of the samples treated with 1.5% simvastatin. The greatest dentin thickness was observed after treatment with 1.5% simvastatin and MTA, followed by 0.5% simvastatin. Statistical analysis demonstrated no significant differences in dentin thickness and continuity between MTA and simvastatin at 0.5% and 1.5% (P > 0.05). |
Databáze: | OpenAIRE |
Externí odkaz: |