Modulation of experimental allergic encephalomyelitis (EAE): suppression of active reinduction of EAE in rats recovered from passively transferred disease
| Autor: | Tatsuhide Kunishita, Tadashi Namikawa, Takeshi Tabira |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adoptive cell transfer
Encephalomyelitis Autoimmune Experimental Time Factors Encephalomyelitis T-Lymphocytes Immunology Central nervous system Cell In vivo Immune Tolerance Immunology and Allergy Medicine Animals Cells Cultured biology business.industry Effector Immunization Passive Myelin Basic Protein medicine.disease In vitro Myelin basic protein Rats medicine.anatomical_structure Neurology Rats Inbred Lew biology.protein Female Neurology (clinical) business |
| Zdroj: | Journal of neuroimmunology. 12(3) |
| ISSN: | 0165-5728 |
| Popis: | Summary Lewis rats that have recovered from EAE induced by the passive transfer of invitro activated lymphocytes sensitized to myelin basic protein showed suppression upon subsequent active reinduction of EAE. This suppression was manifested during the early convalescent stage (up to 30 days after the primary cell transfer) and seemed to be acquired partly idiotype-specifically and partly idiotype-non-specifically. The convalescent rats were fully susceptible to the transfer of sufficient numbers of effector cells, and they could induce pre-effector cells in response to the encephalitogen in vivo as effectively as in naive rats. This suppression was not transferred to naive rats by lymphoid cells from the convalescent rats. The mechanism of this suppression was thought to be a defect in expansion and/or differentiation of pre-effector cells to effector cells in the convalescent rats. |
| Databáze: | OpenAIRE |
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