Variation in 17 oxogenic steroid excretion following oral prednisolone in children with lymphoblastic leukaemia
| Autor: | J.S. Lilleyman, I.P. Young, A.J. French |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Pediatrics Adolescent medicine.medical_treatment Prednisolone Administration Oral Biological Availability Urine Oral prednisolone Steroid Excretion Internal medicine Medicine Humans Urinary concentration Child 17-Hydroxycorticosteroids business.industry General Medicine Leukemia Lymphoid Endocrinology Oncology Child Preschool Creatinine Lymphoblastic leukaemia Patient Compliance 17-Oxogenic steroids Female business medicine.drug |
| Zdroj: | Oncology. 38(5) |
| ISSN: | 0030-2414 |
| Popis: | 19 children in their first remission “fromstandard risk” lymphoblastic leukaemia had the urinary concentration of 17 oxogenic steroids (OGS) measured after two scheduled 5-day courses of prednisolone, only for the second of which were the parents aware of what the urine would be examined for. Despite a carefully standardised dose of the drug, there was a very wide scatter of OGS excretion which changed from time to time with each patient, but not in a way related to when the parents knew what was being measured. 6 low-excreting patients were reassessed in hospital with controlled compliance but only 1 produced her highest level under such circumstances. These results suggest variable bioavailability of prednisolone, but do not indicate the reason. Non-compliance does not appear to be the sole explanation. |
| Databáze: | OpenAIRE |
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