Study of the kinetics of (26- 14 C)cholesterol metabolism in chickens with alimentary hypercholesterolaemia
| Autor: | P. Bobek, V. Chrappa, V. Peter, J. Červeň, V Chorváthová, E. Ginter |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
medicine.medical_specialty
Time Factors Kinetic analysis Kinetics Hypercholesterolemia Biology Cholesterol Dietary chemistry.chemical_compound Plasma cholesterol Internal medicine medicine Methods Animals Cholesterol intake Cholesterol metabolism Carbon Isotopes Cholesterol Total body Endocrinology chemistry Turnover lipids (amino acids peptides and proteins) Female Cardiology and Cardiovascular Medicine Chickens Half-Life |
| Zdroj: | Atherosclerosis. 17(3) |
| ISSN: | 0021-9150 |
| Popis: | The die-away curve after a single intravenous injection of [26- 14 C]cholesterol was studied in normal chickens (standard diet) and in chickens with hypercholesterolaemia (0.5% cholesterol added to diet). The course of the curves indicates that plasma cholesterol turnover in chickens corresponds to the two-pool model. A kinetic analysis of the plasma cholesterol die-away curves in the terms of this model showed that a raised cholesterol intake led in chickens to (a) a decrease in the plasma cholesterol half-life (control: 23, cholesterol-fed group: 13 days), (b) an increase in the amount of cholesterol in the body pool with a rapid cholesterol turnover, (c) an increase in the fractional cholesterol turnover rate in this pool and (d) an increase in the total body cholesterol turnover. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|