Fabrication and characterization of polyvinyl alcohol/metal (Ca, Mg, Ti) doped zirconium phosphate nanocomposite films for scaffold-guided tissue engineering application
| Autor: | Santanu Dhara, Himani Kalita, Pallabi Pal, Amita Pathak |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Nanoparticle chemistry.chemical_element Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Polyvinyl alcohol Nanocomposites Biomaterials Mice chemistry.chemical_compound Animals Magnesium Composite material Titanium Zirconium Nanocomposite Tissue Engineering Tissue Scaffolds integumentary system Doping technology industry and agriculture Membranes Artificial 3T3 Cells Nanoindentation 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Chemical engineering Zirconium phosphate Mechanics of Materials Polyvinyl Alcohol Calcium 0210 nano-technology |
| Zdroj: | Materials Science and Engineering: C. 71:363-371 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2016.09.063 |
| Popis: | Nanocomposite films of polyvinyl alcohol (PVA) and zirconium phosphate (ZrP)/doped ZrP (doped with Ca, Mg, Ti) nanoparticles have been developed by solvent casting method to assess their potential as matrix material in scaffold-guided tissue engineering application. The prepared ZrP and doped ZrP nanoparticles as well as the nanocomposite films were characterized by various spectroscopic and microscopic techniques. Nanoindentation studies revealed improved nanomechanical properties in the PVA/doped ZrP nanocomposite films (highest for PVA/Ti doped ZrP: hardness=262.4MPa; elastic modulus=5800MPa) as compared to the PVA/ZrP and neat PVA films. In-vitro cell culture experiments carried out to access the cellular viability, attachment, proliferation, and migration on the substrates, using mouse fibroblast (3T3) cell lines, inferred enhanced bioactivity in the PVA/doped ZrP nanocomposite films (highest for PVA/Ca doped ZrP) in contrast to PVA/ZrP and neat PVA films. Controlled biodegradability as well as swelling behavior, superior bioactivity and improved mechanical properties of the PVA/doped ZrP nanocomposite films make them promising matrix materials for scaffold-guided tissue engineering application. |
| Databáze: | OpenAIRE |
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