Prospective Validation that Vulnerable Plaque Associated with Major Adverse Outcomes Have Larger Plaque Volume, Less Dense Calcium, and More Non-Calcified Plaque by Quantitative, Three-Dimensional Measurements Using Intravascular Ultrasound with Radiofrequency Backscatter Analysis

Autor: Kenneth Taylor, Hunt Anderson, Sarah Rinehart, James Chun-I Lee, Charles H. Brown, Abhinav Sharma, William Ballard, Zhen Qian, Parag H. Joshi, Laura Murrieta, Jesus G. Vazquez-Figueroa, Szilard Voros, Charles Wilmer, Anna Kalynych, Harold Carlson, Dimitri Karmpaliotis
Rok vydání: 2013
Předmět:
Male
Time Factors
Pharmaceutical Science
Coronary Artery Disease
Coronary Angiography
medicine.disease_cause
Severity of Illness Index
Coronary artery disease
Risk Factors
Intravascular ultrasound
Odds Ratio
Scattering
Radiation
Genetics(clinical)
Prospective Studies
Prospective cohort study
Genetics (clinical)
medicine.diagnostic_test
Middle Aged
Prognosis
Coronary Vessels
Plaque
Atherosclerotic
Predictive value of tests
Disease Progression
Molecular Medicine
Female
Radiology
medicine.symptom
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Georgia
Lumen (anatomy)
Article
Lesion
Necrosis
Imaging
Three-Dimensional
Predictive Value of Tests
Image Interpretation
Computer-Assisted
Genetics
medicine
Humans
cardiovascular diseases
Vascular Calcification
Ultrasonography
Interventional
Vulnerable plaque
Aged
Cardiac events
business.industry
Reproducibility of Results
medicine.disease
Fibrosis
Logistic Models
Multivariate Analysis
Tomography
X-Ray Computed
business
Mace
Zdroj: Journal of Cardiovascular Translational Research
ISSN: 1937-5395
1937-5387
Popis: Whether quantitative, two-dimensional, and three-dimensional plaque measurements by intravascular ultrasound with radiofrequency backscatter (IVUS/VH) are different between intermediate lesions with or without major adverse cardiovascular events (MACE) is unknown. IVUS/VH-derived parameters were compared in 60 patients with an intermediate coronary lesion (40–70 %) between lesions that did or did not result in MACE over 12 months. IVUS/VH measurements were done at the site of the minimal lumen area (MLA) and on a per-plaque basis, defined by 40 % plaque burden. Pre-specified, adjudicated MACE events occurred in 5 of 60 patients (8.3 %). MACE lesions had larger plaque burden (65 % vs. 53 %, p = 0.004), less dense calcium (6.6 % vs. 14.7 %, p = 0.05), and more non-calcified plaque, mostly fibrofatty kind (17.6 % vs. 10 %, p = 0.02). Intermediate coronary lesions associated with MACE at 12 months have more plaque, less dense calcium, and more non-calcified plaque, particularly fibrofatty tissue by IVUS/VH.
Databáze: OpenAIRE
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