Comparison of Cystatin C, Creatinine and Creatinine Clearance vs. GFR for Detection of Renal Failure in Renal Transplant Patients

Autor:	Bruno Moulin, Jean-Philippe Daniel, Maurice Offner, Francois Chantrel, Thierry Hannedouche
Rok vydání:	2004
Předmět:	Adult Male Nephrology medicine.medical_specialty Urology Renal function Kidney Function Tests urologic and male genital diseases Critical Care and Intensive Care Medicine Sensitivity and Specificity Cohort Studies chemistry.chemical_compound Postoperative Complications Predictive Value of Tests Internal medicine medicine Humans Renal Insufficiency Cystatin C Creatinine Inulin Clearance Receiver operating characteristic biology business.industry Cerebrospinal Fluid Proteins General Medicine medicine.disease Cystatins Kidney Transplantation female genital diseases and pregnancy complications Surgery Transplantation ROC Curve chemistry biology.protein Female business Glomerular Filtration Rate Kidney disease
Zdroj:	Renal Failure. 26:253-257
ISSN:	1525-6049 0886-022X
DOI:	10.1081/jdi-120039523
Popis:	Serum cystatin C (Scyst) has been suggested as an alternative index of glomerular filtration rate (GFR) and could be useful in renal transplant patients.In a 60-subject cohort (40 +/- 12 years old), we compared the simultaneous measurements of Scyst, serum creatinine (Screat), creatinine clearance (Ccreat), Cockcroft and Gault's estimated clearance (Ccg) and GFR measured using inulin clearance (Cin). Receiver operating characteristic (ROC) analysis was performed using two Cin cut-off (60 and 90 mL/min/1.73 m2).A significant correlation was found among Cin on one hand and 1/Scyst, Ccreat, 1/Screat and Ccg on the other hand. Best fits (sensitivity/specificity) at 90 mL/min/1.73 m2 were 1.18 mg/L (0.72/0.80) for Scyst, 1.32 mg/dL (0.67/0.90) for Screat, 77 mL/min (0.80/0.70) for Ccg and 104 mL/min (0.88/0.80) for Ccreat. The areas under the ROC curves were not significantly different.This study provides cut-off values for Screat and Ccg for detection of renal failure in renal transplant patients. However, the results also suggest that Scyst is not a more sensitive marker than Screat or Ccg for detecting renal failure in renal transplant patients.
Databáze:	OpenAIRE
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