Association between ANGPTL3, 4, and 8 and lipid and glucose metabolism markers in patients with diabetes

Autor: Yoshinobu Kondo, Yasuo Terauchi, Yasuyuki Sugiura, Akeo Ohira, Mai Sugiyama, Marina Harada, Tadashi Yamakawa, Rie Kashiwagi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Apolipoprotein E
Male
Physiology
Hydrolases
Peptide Hormones
Biochemistry
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Medical Conditions
Glucose Metabolism
Blood plasma
Medicine and Health Sciences
Lipases
Aged
80 and over
Lipoprotein lipase
Multidisciplinary
Middle Aged
Lipids
Lipid Profiles
Body Fluids
Enzymes
Blood
Physiological Parameters
Carbohydrate Metabolism
Medicine
Female
lipids (amino acids
peptides
and proteins)
Anatomy
Research Article
Adult
medicine.medical_specialty
Endocrine Disorders
Lipoproteins
Science
Carbohydrate metabolism
Blood Plasma
03 medical and health sciences
Angiopoietin-Like Protein 8
Internal medicine
Diabetes mellitus
medicine
Diabetes Mellitus
Angiopoietin-Like Protein 4
Humans
Obesity
Triglycerides
Aged
Angiopoietin-Like Protein 3
Triglyceride
business.industry
Hypertriglyceridemia
Body Weight
Biology and Life Sciences
Proteins
Lipid metabolism
medicine.disease
Lipid Metabolism
030104 developmental biology
Angiopoietin-like Proteins
Glucose
Metabolism
chemistry
Metabolic Disorders
Enzymology
business
030217 neurology & neurosurgery
Biomarkers
Zdroj: PLoS ONE, Vol 16, Iss 7, p e0255147 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: Lipid management, especially with respect to triglyceride (TG) metabolism, in patients with diabetes is not sufficient with current therapeutic agents, and new approaches for improvement are needed. Members of the angiopoietin-like protein (ANGPTL) family, specifically ANGPTL3, 4, and 8, have been reported as factors that inhibit lipoprotein lipase (LPL) activity and affect TGs. The present study investigated the association between lipid and glucose metabolism markers and the mechanism by which these proteins affect lipid metabolism. A total of 84 patients hospitalized for diabetes treatment were evaluated. Lipid and glucose metabolism markers in blood samples collected before breakfast, on the day after hospitalization, were analyzed. ANGPTL8 showed a significant positive correlation with TG values. HDL-C values displayed a significant positive correlation with ANGPTL3 but a negative correlation with ANGPTL4 and ANGPTL8. The results did not indicate a significant correlation among ANGPTL3, 4, and 8 levels. Thus, it is possible that the distribution of these proteins differs among patients. When patients were divided into groups according to the levels of ANGPTL3 and ANGPTL8, those with high levels of both ANGPTL3 and ANGPTL8 also had high levels of TG and small dense LDL-C/LDL-C (%). Multiple regression analysis indicated that low LPL, high ApoC2, high ApoC3, high ApoE, and high ANGPTL8 levels were the determinants of fasting hypertriglyceridemia. By contrast, no clear association was observed between any of the ANGPTLs and glucose metabolism markers, but ANGPTL8 levels were positively correlated with the levels of HOMA2-IR and BMI. Patients with high levels of both ANGPTL3 and ANGPTL8 had the worst lipid profiles. Among ANGPTL3, 4, and 8, ANGPTL8 is more important as a factor determining plasma TG levels. We anticipate that the results of this research will facilitate potential treatments targeting ANGPTL8 in patients with diabetes.
Databáze: OpenAIRE
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