Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy
Autor: | Wei Zhuo, Wei Zhang, Zhao-Qian Liu, Hong-Hao Zhou, Tao Zhu, Juyan Zheng, Jun-Luan Mo, Yueneng Yi, Ji-Ye Yin, Shuo Hu |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Cancer Research cGAS-STING Carcinogenesis Review Biology lcsh:RC254-282 Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Immunity Neoplasms Humans Type I interferon Antitumor response Inflammation Innate immunity Innate immune system Effector Membrane Proteins Acquired immune system lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Nucleotidyltransferases eye diseases Immunity Innate STING agonists Sting Cancer development 030104 developmental biology Oncology 030220 oncology & carcinogenesis Stimulator of interferon genes Immunology Interferon Type I Molecular Medicine Immunotherapy Signal transduction Signal Transduction |
Zdroj: | Molecular Cancer Molecular Cancer, Vol 19, Iss 1, Pp 1-19 (2020) |
ISSN: | 1476-4598 |
Popis: | Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its downstream effector, stimulator of interferon genes (STING), are involved in mediating fundamental innate antimicrobial immunity by promoting the release of type I interferons (IFNs) and other inflammatory cytokines. Accumulating evidence suggests that the activation of the cGAS-STING axis is critical for antitumor immunity. The downstream cytokines regulated by cGAS-STING, especially type I IFNs, serve as bridges connecting innate immunity with adaptive immunity. Accordingly, a growing number of studies have focused on the synthesis and screening of STING pathway agonists. However, chronic STING activation may lead to a protumor phenotype in certain malignancies. Hence, the cGAS-STING signaling pathway must be orchestrated properly when STING agonists are used alone or in combination. In this review, we discuss the dichotomous roles of the cGAS-STING pathway in tumor development and the latest advances in the use of STING agonists. |
Databáze: | OpenAIRE |
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