Stressing on the nucleolus in cardiovascular disease
| Autor: | Mark A. Sussman, Nirmala Hariharan |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Nucleolus
Ribosome biogenesis RNA-binding protein Biology Fibrillins Cardiovascular Article Stress Response Signaling Organelle Humans Disease Molecular Biology Cell Proliferation Cell growth Microfilament Proteins Nuclear Proteins RNA-Binding Proteins Heart Microfilament Protein Phosphoproteins Cell biology Cardiovascular Diseases Molecular Medicine Signal transduction Nucleophosmin Cell Nucleolus Signal Transduction |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (6):798-801 |
| ISSN: | 0925-4439 |
| DOI: | 10.1016/j.bbadis.2013.09.016 |
| Popis: | The nucleolus is a multifunctional organelle with multiple roles involving cell proliferation, growth, survival, ribosome biogenesis and stress response signaling. Alteration of nucleolar morphology and architecture signifies an early response to increased cellular stress. This review briefly summarizes nucleolar response to cardiac stress signals and details the role played by nucleolar proteins in cardiovascular pathophysiology. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease. |
| Databáze: | OpenAIRE |
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