Prognostic Value of CD44 Variant exon 6 Expression in Non-Small Cell Lung Cancer: a Meta-analysis
| Autor: | Wei-Min Li, Bo-Jiang Chen, Shuang Zhao, Jin-Lan He, Zhixin Qiu, Zhuang Luo, Nian-Yong Chen |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Pathology Lung Neoplasms Epidemiology Adenocarcinoma Metastasis Carcinoma Non-Small-Cell Lung Internal medicine Biomarkers Tumor Carcinoma Humans Protein Isoforms Medicine Neoplasm Invasiveness Lung cancer biology business.industry CD44 Hazard ratio Public Health Environmental and Occupational Health Prognosis medicine.disease Confidence interval Hyaluronan Receptors Lymphatic Metastasis Meta-analysis Carcinoma Squamous Cell Disease Progression biology.protein Female business |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 15:6761-6766 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2014.15.16.6761 |
| Popis: | Background: CD44v6 (CD44 variant exon 6) is the chief CD44 variant isoform regulating tumor invasion, progression, and metastasis. The prognostic value of CD44v6 expression in non small cell lung cancer (NSCLC) has been evaluated in many studies, but the results have remained controversial. Thus, we performed a meta- analysis of currently available studies to investigate the prognostic value of CD44v6 expression in NSCLC patients and the relationship between the expression of CD44v6 and clinicopathological features. Materials and Methods: Two independent reviewers searched the relevant literature in Pubmed, Medline and Embase from 1946 to January 2014. Overall survival (OS) and various clinicopathological features were collected from included studies. This meta-analysis was accomplished using STATA 12.0 and Revman 5.2 software. Pooled hazard ratios (HRs) with 95% confidence intervals (95%CIs) were calculated to estimate the effects. Results: A total of 921 NSCLC patients from ten studies met the inclusion criteria. The results showed that CD44v6 high expression was a prognostic factor for poor survival (HR=1.91, 95%CI=1.12-3.26, p |
| Databáze: | OpenAIRE |
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