Increased erythrocyte- and platelet-derived microvesicles in newly diagnosed type 2 diabetes mellitus
| Autor: | Antonios Lazaridis, Eugenia Gkaliagkousi, Panagiota Anyfanti, Dimitra Markala, Efthalia Yiannaki, Barbara Nikolaidou, Stella Douma, Eleni Gavriilaki, Ioanna Zografou |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Blood Glucose Blood Platelets Glycation End Products Advanced Male medicine.medical_specialty Erythrocytes Endocrinology Diabetes and Metabolism Newly diagnosed 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Cell-Derived Microparticles Internal medicine Diabetes mellitus Internal Medicine Humans Medicine Platelet Glycated haemoglobin Aged 030304 developmental biology Glycated Hemoglobin 0303 health sciences business.industry Type 2 Diabetes Mellitus Thrombosis Middle Aged medicine.disease Microvesicles Cross-Sectional Studies Diabetes Mellitus Type 2 Case-Control Studies Female Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Diabetes and Vascular Disease Research. 16:458-465 |
| ISSN: | 1752-8984 1479-1641 |
| DOI: | 10.1177/1479164119844691 |
| Popis: | Aim: To investigate the thrombotic microenvironment in early stages of type 2 diabetes mellitus measuring platelet-derived, endothelial-derived and erythrocyte-derived microvesicles. Methods: We recruited 50 newly diagnosed type 2 diabetes mellitus patients who did not receive glucose-lowering treatment except for metformin and 25 matched non-type 2 diabetes mellitus volunteers. Microvesicles were measured with flow cytometry, glycated haemoglobin with high-performance liquid chromatography and advanced glycation end products with enzyme-linked immunosorbent assay. Results: Type 2 diabetes mellitus patients showed significantly higher levels of platelet-derived microvesicles [195/μL (115–409) vs 110/μL (73–150), p = 0.001] and erythrocyte-derived microvesicles [26/μL (9–100) vs 9/μL (4–25), p = 0.007] compared to non-type 2 diabetes mellitus individuals. Platelet-derived microvesicles were positively associated with fasting blood glucose ( p = 0.026) and glycated haemoglobin ( p = 0.002). Erythrocyte-derived microvesicles were also positively associated with fasting blood glucose ( p = 0.018) but not with glycated haemoglobin ( p = 0.193). No significant association was observed between platelet-derived microvesicles ( p = 0.126) or erythrocyte-derived microvesicles ( p = 0.857) and advanced glycation end products. Erythrocyte-derived microvesicles predicted the presence of type 2 diabetes mellitus, independently of platelet-derived microvesicles. Conclusion: In newly diagnosed type 2 diabetes mellitus, ongoing atherothrombosis is evident during the early stages as evidenced by increased microvesicles levels. Furthermore, the association with glycemic profile suggests that microvesicles represent not only a novel mechanism by which hyperglycemia amplifies thrombotic tendency in type 2 diabetes mellitus but also early markers of thrombosis highlighting the need for earlier management of hyperglycemia. |
| Databáze: | OpenAIRE |
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