Low-level laser therapy can reduce lipopolysaccharide-induced contractile force dysfunction and TNF-α levels in rat diaphragm muscle
| Autor: | Marcos Tadeu Tavares Pacheco, Flavio Aimbire, Rodrigo Álvaro Brandão Lopes-Martins, P. S. L. M. Leonardo, Regiane Albertini, V. V. Iversen, Maria Cristina Chavantes, Hugo C. Castro-Faria-Neto, Jan Magnus Bjordal |
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| Rok vydání: | 2006 |
| Předmět: |
Lipopolysaccharides
Male medicine.medical_specialty Lipopolysaccharide Chlorpromazine Electrical muscle stimulation medicine.medical_treatment Diaphragm Stimulation Dermatology Random Allocation chemistry.chemical_compound Internal medicine medicine Animals Respiratory function Low-Level Light Therapy Rats Wistar Low level laser therapy Tumor Necrosis Factor-alpha business.industry Rats Endocrinology chemistry Immunology Surgery Tumor necrosis factor alpha Rat Diaphragm Respiratory Insufficiency business medicine.drug |
| Zdroj: | Lasers in Medical Science. 21:238-244 |
| ISSN: | 1435-604X 0268-8921 |
| DOI: | 10.1007/s10103-006-0405-y |
| Popis: | Our objective was to investigate if low-level laser therapy (LLLT) could improve respiratory function and inhibit tumor necrosis factor (TNF-alpha) release into the diaphragm muscle of rats after an intravenous injection of lipopolysaccharide (LPS) (5 mg/kg). We randomly divided Wistar rats in a control group without LPS injection, and LPS groups receiving either (a) no therapy, (b) four sessions in 24 h with diode Ga-AsI-Al laser of 650 nm and a total dose of 5.2 J/cm2, or (c) an intravenous injection (1.25 mg/kg) of the TNF-alpha inhibitor chlorpromazine (CPZ). LPS injection reduced maximal force by electrical stimulation of diaphragm muscle from 24.15+/-0.87 N in controls, but the addition of LLLT partly inhibited this reduction (LPS only: 15.01+/-1.1 N vs LPS+LLLT: 18.84+/-0.73 N, P0.05). In addition, this dose of LLLT and CPZ significantly (P0.05 and P0.01, respectively) reduced TNF-alpha concentrations in diaphragm muscle when compared to the untreated control group. |
| Databáze: | OpenAIRE |
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