Deficiency of hMLH1 and hMSH2 expression is a poor prognostic factor in esophageal squamous cell carcinoma
| Autor: | Akira Fukunaga, Masaki Miyamoto, Soichi Murakami, Hirofumi Uehara, T Kurokawa, You Kawarada, Yosihiro Murakami, Yasushi Cho, Yuma Ebihara, Shunichi Okushiba, Kentaro Kato, Satoshi Kondo, Hiroyuki Katoh, Toshiaki Shichinohe, Hiroyuki Kaneko, Hiroyuki Hashimoto, Tomoo Itoh |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Oncology congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty DNA Repair Esophageal Neoplasms Base Pair Mismatch MLH1 Malignancy Esophageal squamous cell carcinoma Internal medicine medicine Humans neoplasms Gene Adaptor Proteins Signal Transducing Aged business.industry Nuclear Proteins nutritional and metabolic diseases General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry digestive system diseases Survival Rate MutS Homolog 2 Protein MSH2 Multivariate Analysis Carcinoma Squamous Cell Female Surgery DNA mismatch repair Lymph Carrier Proteins MutL Protein Homolog 1 business |
| Zdroj: | Journal of Surgical Oncology. 92:109-115 |
| ISSN: | 1096-9098 0022-4790 |
| Popis: | Background The human Mut-L-Homologon-1 (MLH1) and Mut-S-Homologon-2 (MSH2) are post replication mismatch repair (MMR) genes. Methods We examined the correlation of the clinical features of 122 patients with esophageal squamous cell carcinoma (ESCC) with the expression of MLH1 and MSH2 by immunohistochemical analysis. Results According to our criteria, 34 and 25 cases did not express MLH1 and MSH2, respectively. Expression of both the MLH1 and MSH2 gene products was observed in 73 (59.8%) cases; loss of MLH1 or MSH2 expression was detected in 35(28.7%) cases. Fourteen (11.5%) cases demonstrated loss of both MLH1 and MSH2 expression in ESCC. Loss of MLH1 and/or MSH2 gene expression significantly correlated with increases in malignancy, as evidenced by increases in the existence of metastatic lymph nodes (P = 0.0056), extensive invasion (P = 0.0007), and poor differentiation (P = 0.0992). The MLH1-negative patients had a significantly poorer prognosis than those in the MLH1-positive group (P = 0.0043). Similar results were observed for MSH2 expression (P = 0.0002). Patients both MLH1 and MSH2 negative exhibited the most poor clinical outcome than other patients (P |
| Databáze: | OpenAIRE |
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