Effects of Ambient Air Pollution on Hemostasis and Inflammation
| Autor: | Evren Kilinc, Moniek P.M. de Maat, Goran Rudež, Henri M. H. Spronk, Miriam E. Gerlofs-Nijland, Hugo ten Cate, Nicole A.H. Janssen, Flemming R. Cassee, Frank W.G. Leebeek |
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| Přispěvatelé: | Internal Medicine, Hematology |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Pollution
Adult Male medicine.medical_specialty Platelet aggregation Platelet Aggregation Health Toxicology and Mutagenesis media_common.quotation_subject Pharmacology toxicology air pollution Inflammation blood coagulation Air pollutants SDG 3 - Good Health and Well-being cardiovascular disease Internal medicine medicine Humans Respiratory system media_common Air Pollutants Hemostasis Ambient air pollution Research Public Health Environmental and Occupational Health Thrombin Fibrinogen Middle Aged C-Reactive Protein Immunology Cardiology Environmental science Female Particulate Matter medicine.symptom |
| Zdroj: | Environmental Health Perspectives Environmental Health Perspectives, 117(6), 995-1001. Public Health Services, US Dept of Health and Human Services |
| ISSN: | 1552-9924 0091-6765 |
| Popis: | BACKGROUND: Air pollution has consistently been associated with increased morbidity and mortality due to respiratory and cardiovascular disease. Underlying biological mechanisms are not entirely clear, and hemostasis and inflammation are suggested to be involved. OBJECTIVES: Our aim was to study the association of the variation in local concentrations of airborne particulate matter (PM) with aerodynamic diameter < 10 mu m, carbon monoxide, nitrogen monoxide, nitrogen dioxide, and ozone with platelet aggregation, thrombin generation, fibrinogen, and C-reactive protein (CRP) levels in healthy individuals. METHODS: From 40 healthy volunteers, we collected 13 consecutive blood samples within a 1-year period and measured light-transmittance platelet aggregometry, thrombin generation, fibrinogen, and CRP. We performed regression analysis using generalized additive models to study the association between the hemostatic and inflammatory variables, and local environmental concentrations 0 air pollutants for time lags within 24 hr before blood sampling or 24-96 hr before blood sampling. RESULTS: In general, air pollutants were associated with platelet aggregation [average, +8% per interquartile range (IQR), p < 0.01] and thrombin generation (average, +1% per IQR, p < 0.015). Platelet aggregation was not affected by in vitro incubation of plasma with PM. We observed no relationship between any of the air pollutants and fibrinogen or CRP levels. CONCLUSIONS:. Air pollution increased platelet aggregation as well as coagulation activity but had no clear effect on systemic inflammation. These prothrombotic effects may partly explain the relationship between air pollution and the risk of ischemic cardiovascular disease. |
| Databáze: | OpenAIRE |
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