Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives
| Autor: | Sajal Afzal, Chae-Ok Yun, Eonju Oh, Ye Liu, Renu Wadhwa, Ran Gao, Sunil C. Kaul, Sukant Garg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research cell migration Ashwagandha Vimentin Matrix metalloproteinase lcsh:RC254-282 Metastasis 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation In vivo medicine metastasis Original Research therapy biology Chemistry Wnt signaling pathway Cell migration TEG TEG-derivatives lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease invasion In vitro 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research biology.protein |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 8 (2018) |
| ISSN: | 2234-943X |
| Popis: | We had previously reported anticancer activity in the water extract (WEX) of Ashwagandha leaves, and identified Triethylene glycol (TEG) as an active tumor suppressor component. In this study, we investigated anti-migratory and anti-angiogenesis activities of WEX and TEG. We conducted in vitro and in vivo experiments using TEG, and its two derivatives, Triethyleneglycol dimethacrylate (TD-10), and Tetraethyleneglycol dimethacrylate (TD-11). The data revealed strong anticancer and anti-metastasis potentials in the derivatives. Non-toxic, anti-migratory doses of the derivatives showed inhibition of canonical Wnt/β-catenin axis and consequent downregulation of EMT-signaling proteins (Vimentin, MMPs and VEGF). These results endorse that the TD-10 and TD-11 have potential to safely put a check on the aggressiveness of the metastatic cells and therefore represent promising candidates for the treatment of metastatic cancers. |
| Databáze: | OpenAIRE |
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