Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction
| Autor: | D Deitchman, L R Burwell, N Gustafson, B S George, Richard R. Heuser, J W Gruber, Bruce R. Pitt, D A Rothbaum, D J Kereiakes, John T. Flaherty |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Myocardial Infarction Myocardial Reperfusion Injury Placebo Ventricular Function Left Physiology (medical) Internal medicine Angioplasty medicine Humans Myocardial infarction Angioplasty Balloon Coronary Chemotherapy Superoxide Dismutase business.industry Vascular disease Gated Blood-Pool Imaging Middle Aged medicine.disease Free radical scavenger Recombinant Proteins Clinical trial Anesthesia Electrocardiography Ambulatory Cardiology Female Cardiology and Cardiovascular Medicine business Reperfusion injury |
| Zdroj: | Circulation. 89:1982-1991 |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | BACKGROUND Animal studies have demonstrated a burst of oxygen free radical generation after reperfusion of ischemic myocardium that could be blocked by administration of the free radical scavenger recombinant human superoxide dismutase (h-SOD). A multicenter, randomized, placebo-controlled clinical trial was designed to test the hypothesis that free radical-mediated reperfusion injury could be reduced by intravenous administration of h-SOD begun before percutaneous transluminal coronary angioplasty (PTCA) in patients with acute transmural myocardial infarction. METHODS AND RESULTS One hundred twenty patients were randomized to receive placebo (n = 59) or h-SOD (n = 61) given as a 10-mg/kg intravenous bolus followed by a 60-minute infusion of 0.2 mg.kg-1.min-1. Left ventricular function was analyzed via paired contrast left ventriculograms performed before PTCA and after 6 to 10 days and paired radionuclide ventriculograms performed within 24 hours of PTCA and after 4 to 6 weeks. Both h-SOD- and placebo-treated patients showed improvement in global and regional left ventricular function after successful reperfusion. Compared with the placebo group, no additional improvement was observed in the patients treated with h-SOD. CONCLUSIONS The results of this clinical trial failed to demonstrate a beneficial effect of h-SOD on global or regional left ventricular function in patients who underwent successful PTCA for treatment of acute myocardial infarction. |
| Databáze: | OpenAIRE |
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