Exploring the Preparation of Albendazole-Loaded Chitosan-Tripolyphosphate Nanoparticles
| Autor: | Jin-Ki Kim, Jeong-Sook Park, Sang-Eun Lee, Choon Lian Ng, Bong-Seok Kang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Materials science
Sonication Dispersity albendazole Nanoparticle lcsh:Technology tripolyphosphate Article Chitosan Acetic acid chemistry.chemical_compound Zeta potential General Materials Science Solubility lcsh:Microscopy lcsh:QC120-168.85 anti-cancer effect Chromatography lcsh:QH201-278.5 lcsh:T nanoparticle chemistry lcsh:TA1-2040 lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering Particle size chitosan lcsh:Engineering (General). Civil engineering (General) lcsh:TK1-9971 |
| Zdroj: | Materials Volume 8 Issue 2 Pages 486-498 Materials, Vol 8, Iss 2, Pp 486-498 (2015) MATERIALS(8): 2 |
| ISSN: | 1996-1944 |
| DOI: | 10.3390/ma8020486 |
| Popis: | The objective of this study was to improve the solubility of albendazole and optimize the preparation of an oral nanoparticle formulation, using beta-cyclodextrin (beta CD) and chitosan-tripolyphosphate (TPP) nanoparticles. The solubility of albendazole in buffers, surfactants, and various concentrations of acetic acid solution was investigated. To determine drug loading, the cytotoxic effects of the albendazole concentration in human hepatocellular carcinoma cells (HepG2) were investigated. The formulations were prepared by mixing the drug solution in Tween 20 with the chitosan solution. TPP solution was added dropwise with sonication to produce a nanoparticle through ionic crosslinking. Then the particle size, polydispersity index, and zeta potential of the nanoparticles were investigated to obtain an optimal composition. The solubility of albendazole was greater in pH 2 buffer, Tween 20, and beta CD depending on the concentration of acetic acid. Drug loading was determined as 100 mu g/mL based on the results of cell viability. The optimized ratio of Tween 20, chitosan/hydroxypropyl beta CD, and TPP was 2:5:1, which resulted in smaller particle size and proper zeta positive values of the zeta potential. The chitosan-TPP nanoparticles increased the drug solubility and had a small particle size with homogeneity in formulating albendazole as a potential anticancer agent. |
| Databáze: | OpenAIRE |
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