Effect of n-3 fatty acids supplementation during life style modification in women with overweight
| Autor: | Pavel Sedláček, Petra Buňatová, Luděk Müller, Iveta Plavinova, Jaroslav Novak, Ladislav Trefil, Jana Dvořáková, Jana Langmajerová, Dana Müllerová, Vaclav Zeman |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Docosahexaenoic Acids Overweight 03 medical and health sciences Lifestyle modification Internal medicine medicine Potency Humans N-3 fatty acids Healthy Lifestyle Adiponectin Life style business.industry Public Health Environmental and Occupational Health General Medicine Eicosapentaenoic acid nadváha životní styl EPA inzulínová rezistence 030104 developmental biology Endocrinology Treatment Outcome Eicosapentaenoic Acid overweight life style EPA insuline resistance Docosahexaenoic acid Dietary Supplements lipids (amino acids peptides and proteins) Female medicine.symptom business |
| Zdroj: | Central European journal of public health. 26(4) |
| ISSN: | 1210-7778 |
| Popis: | The marine n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) exert numerous beneficial effects on health, but their potency to defend against development of peripheral insulin resistance of healthy person with overweight remains poorly characterized. We aimed to evaluate the effect of a combination intervention using EPA + DHA and the lifestyle modification (LSM) in women with overweight.In a parallel-group, three-arm, randomized trial (UMIN Clinical Trials Registry - R000031131), 34 women were assigned to a 12-week-intervention using corn oil (1.5 g/day; placebo); LSM and corn oil (1.5 g/day; LSM); or LSM and EPA + DHA concentrate (1.5 g/day, containing ~ 0.6 g EPA + DHA; LSMn-3). At baseline and after intervention, anthropometric measurements including bioelectrical impedance analysis, spiroergometry, 24-hours dietary recall, and various metabolic markers, adiponectin and cytokines were evaluated in serum using standard procedures. Data from 29 women were used for the final evaluation. Wilcoxon two-sided rank-sum test was used to inspect the differences between LSM and LSMn-3, and placebo groups, with a p-value of ≤ 0.05. All computations were performed with MATLAB Statistics Toolbox.In comparison with placebo, LSM and LSMn-3 decreased body weight, waist circumference, and body fat, and increased VOBesides preventing a modest negative effect of LSM on IL6 and adiponectin level, the combination of LSM and EPA + DHA supplementation could be probably used to improve the functional capacity of adipose tissue in women with overweight. |
| Databáze: | OpenAIRE |
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