Are serum α- and β-carotene concentrations associated with the development of advanced beta-cell autoimmunity in children with increased genetic susceptibility to type 1 diabetes?
| Autor: | Olli Simell, Hanna-Mari Takkinen, Mikael Knip, Jorma Ilonen, G. Alfthan, Liisa Uusitalo, Marianne Prasad, Michael G. Kenward, Marja-Leena Ovaskainen, Jaakko Nevalainen, Suvi M. Virtanen, Riitta Veijola |
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| Rok vydání: | 2011 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Autoimmunity 030209 endocrinology & metabolism medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Endocrinology HLA Antigens Pregnancy Insulin-Secreting Cells Diabetes mellitus Internal Medicine medicine Genetic predisposition Humans Genetic Predisposition to Disease Seroconversion Child Beta (finance) 030304 developmental biology 0303 health sciences Type 1 diabetes business.industry Infant General Medicine beta Carotene medicine.disease Carotenoids Diabetes Mellitus Type 1 Case-Control Studies Child Preschool Immunology Gestation Female business |
| Zdroj: | Diabetes & Metabolism. 37:162-167 |
| ISSN: | 1262-3636 |
| DOI: | 10.1016/j.diabet.2010.10.002 |
| Popis: | Aim Reactive oxygen intermediates have been implicated in mediating the destruction of insulin-producing beta cells and antioxidant nutrients thought to protect against such a process. This study aimed to assess the associations between serum α- and β-carotene concentrations, and the risk of advanced beta-cell autoimmunity, in children with HLA-conferred susceptibility to type 1 diabetes. Methods This case-control study, comprising 108 case children with advanced beta-cell autoimmunity and 216 matched control children, was nested within the nutrition study of the Type 1 Diabetes Prediction and Prevention (DIPP) birth cohort. Serum α- and β-carotene samples were collected each year from the age of 1 to 6years. For each case-control group, serum samples were analyzed up to the time of seroconversion in the case children. Associations were studied using a conditional logistic-regression model. Results Neither serum α- nor β-carotene concentration was significantly associated with the risk of advanced beta-cell autoimmunity. There was marginal evidence ( P =0.049) of an inverse association between serum β-carotene concentration and the risk of developing advanced beta-cell autoimmunity at a time closest to seroconversion after adjusting for parental education, maternal age, duration of gestation, diabetes in first-degree relatives, number of earlier deliveries and maternal smoking during pregnancy. Conclusion The present study data provided no clear evidence to support an association between serum α- or β-carotene concentration and advanced beta-cell autoimmunity. |
| Databáze: | OpenAIRE |
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