Mitochondrial dysfunction in human pathologies
| Autor: | Sara Borniquel, María Monsalve, Inmaculada Valle, Santiago Lamas |
|---|---|
| Přispěvatelé: | Ministerio de Educación y Ciencia (España), Fundación Pro CNIC, Bancaja, Centro Nacional de Investigaciones Oncológicas (España), Sociedad Española de Nefrología |
| Rok vydání: | 2007 |
| Předmět: |
Mitochondrial ROS
Gerontology Aging Cell education Mitochondrion medicine.disease_cause Nitric Oxide Nitric oxide chemistry.chemical_compound Neoplasms medicine Humans Transcription factor chemistry.chemical_classification Reactive oxygen species business.industry Neurodegenerative Diseases Cell biology Mitochondria Oxidative Stress medicine.anatomical_structure chemistry business Reactive Oxygen Species Oxidative stress Function (biology) Transcription Factors |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | The integrity of mitochondrial function is fundamental to cell life. The cell demands for mitochondria and their complex integration into cell biology, extends far beyond the provision of ATP. It follows that disturbances of mitochondrial function lead to disruption of cell function, expressed as disease or even death. Mitochondria are major producers of free radical species and also possibly of nitric oxide, and are, at the same time, major targets for oxidative damage. In this review we consider recent developments in our knowledge of how the mitochondrial production of reactive oxygen species (ROS) plays a critical role in several major human pathologies. We will also consider recent advances in our understanding of the molecular mechanisms involved in mitochondrial ROS detoxification. This work was supported by an institutional grant from the CNIC, by Plan Nacional de I+D+I grants SAF2003-01039 and SAF2003-04901 and grant-in-aid from the Spanish Society of Nephrology to Dr. Santiago Lamas. Sara Borniquel is holder of grant SAF2003-04901 predoctoral fellowship. Inmaculada Valle is holder of a CNIC-Bancaja predoctoral fellowship. Maria Monsalve is holder of a Ramon y Cajal contract from the Ministerio de Educación y Ciencia. |
| Databáze: | OpenAIRE |
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