Stimulation of prostate cancer growth by androgens and estrogens through the intermediacy of sex hormone-binding globulin
| Autor: | Atif M. Nakhla, William Rosner |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Endocrinology Sex hormone-binding globulin Sex Hormone-Binding Globulin Internal medicine Cyclic AMP Tumor Cells Cultured medicine Humans Protein Phosphatase Inhibitor Receptor Estradiol biology Chemistry Prostatic Neoplasms Dihydrotestosterone Sex hormone receptor Thionucleotides Steroid hormone Estrogen biology.protein Cell Division hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| Zdroj: | Endocrinology. 137:4126-4129 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo.137.10.8828467 |
| Popis: | Sex hormone-binding globulin (SHBG) not only regulates the free concentration of certain steroid sex hormones in plasma, but is involved in a nongenomic mechanism of steroid hormone action. It binds to a receptor on prostatic cell membranes and is activated by an appropriate steroid to initiate the generation of intracellular cAMP. Using the human prostate cancer cell line ALVA-41, we show that in serum-free medium, both dihydrotestosterone and estradiol increase growth in the presence, but not the absence, of SHBG. The increase in growth also follows the addition of cAMP to the cells and is enhanced by inhibiting protein dephosphorylation with the protein phosphatase inhibitor, okadaic acid. We conclude that cAMP causes increased growth in this prostate cancer cell line, and that both SHBG-dihydrotestosterone and SHBG-estradiol can regulate intracellular cAMP, and hence growth, in these cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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