Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy

Autor: Ronald van Ree, Rachel Babic, Ewa Pietraszewicz, Bunmi Raji, Erin Thompson, Joanna Craven, Gillian Regis, Henry T. Bahnson, Carsten Flohr, Suzana Radulovic, Victoria Offord, Lorna Wheatley, Jason Cullen, Ben Stockwell, Victor Turcanu, Gideon Lack, Katherine Taylor, Anna Tseng, Devi Patkunam, Michael R. Perkin, Yasmin Kahnum, Kerry Richards, Kirsty Logan, Serge A. Versteeg, Alick Stephens, Mary DeSousa, E.N. Mills, Sharon Tonner, Louise Young, Asha Sudra, Charlotte Stedman, Emily Banks, Sarah Byrom, Tom Marrs, Charlie Bigwood
Přispěvatelé: Experimental Immunology, APH - Global Health, APH - Personalized Medicine, Ear, Nose and Throat, AII - Inflammatory diseases
Rok vydání: 2018
Předmět:
Male
Pediatrics
breastfeeding
Breastfeeding
law.invention
0302 clinical medicine
Randomized controlled trial
law
Immunology and Allergy
adherence
030212 general & internal medicine
SCORAD
2. Zero hunger
medicine.diagnostic_test
3. Good health
Breast Feeding
Child
Preschool
Infant Food
EAT
Enquiring About Tolerance
medicine.medical_specialty
Immunology
SIG
Standard introduction group
Article
LEAP
Learning Early About Peanut
SCORAD
Scoring Atopic Dermatitis
03 medical and health sciences
Food allergy
Statistical significance
medicine
Immune Tolerance
Humans
allergens
EIG
Early introduction group
infancy
Egg Hypersensitivity
business.industry
Infant
Odds ratio
Immunoglobulin E
medicine.disease
Regimen
030228 respiratory system
Desensitization
Immunologic
Egg allergy
randomized controlled trial
diet
business
OR
Odds ratio
Follow-Up Studies
Zdroj: Enquiring About Tolerance (EAT) study team 2019, ' Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy ', The Journal of allergy and clinical immunology, vol. 144, no. 6, pp. 1606-1614.e2 . https://doi.org/10.1016/j.jaci.2019.06.045
Journal of allergy and clinical immunology, 144(6), 1606-1614.e2. Mosby Inc.
The Journal of Allergy and Clinical Immunology
ISSN: 1097-6825
0091-6749
DOI: 10.1016/j.jaci.2019.06.045
Popis: Background The Enquiring About Tolerance (EAT) study was a randomized trial of the early introduction of allergenic solids into the infant diet from 3 months of age. The intervention effect did not reach statistical significance in the intention-to-treat analysis of the primary outcome. Objective We sought to determine whether infants at high risk of developing a food allergy benefited from early introduction. Methods A secondary intention-to-treat analysis was performed of 3 groups: nonwhite infants; infants with visible eczema at enrollment, with severity determined by SCORAD; and infants with enrollment food sensitization (specific IgE ≥0.1 kU/L). Results Among infants with sensitization to 1 or more foods at enrollment (≥0.1 kU/L), early introduction group (EIG) infants developed significantly less food allergy to 1 or more foods than standard introduction group (SIG) infants (SIG, 34.2%; EIG, 19.2%; P = .03), and among infants with sensitization to egg at enrollment, EIG infants developed less egg allergy (SIG, 48.6%; EIG, 20.0%; P = .01). Similarly, among infants with moderate SCORAD (15
Graphical abstract
Databáze: OpenAIRE
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