Mechanistic Understanding of Competitive Destabilization of Carbamazepine Cocrystals under Solvent Free Conditions
| Autor: | Mhd. Bashir Alsirawan, Petroc Shelley, Thomas J. Bannan, Xiaojun Lai, Venu R. Vangala, Rafel Prohens, David Topping, Anant Paradkar |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Fusion
Solvent free 010405 organic chemistry Chemistry Vapor pressure General Chemistry 010402 general chemistry Condensed Matter Physics Green manufacturing 01 natural sciences 0104 chemical sciences Crystal Computational chemistry Phase (matter) General Materials Science Sublimation (phase transition) Eutectic system |
| Zdroj: | Crystal Growth & Design. 20:6024-6029 |
| ISSN: | 1528-7505 1528-7483 |
| DOI: | 10.1021/acs.cgd.0c00735 |
| Popis: | Mechanistic understanding of competitive destabilization of carbamazepine:nicotinamide and carbamazepine:saccharin cocrystals under solvent free conditions has been investigated. The crystal phase transformations were monitored using hot stage microscopy, variable-temperature powder X-ray diffraction, and sublimation experiments. The destabilization of the two cocrystals occurs via two distinct mechanisms: vapor and eutectic phase formations. Vapor pressure measurements and thermodynamic calculations using fusion and sublimation enthalpies were in good agreement with experimental findings. The mechanistic understanding is important to maintain the stability of cocrystals during solvent free green manufacturing. |
| Databáze: | OpenAIRE |
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