p27 Is a Critical Prognostic Biomarker in Non-Alcoholic Steatohepatitis-Related Hepatocellular Carcinoma

Autor: Shun Fujimaki, Yasunobu Matsuda, Mami Osawa, Toshifumi Wakai, Masayuki Kubota, Yuki Hirose
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
Pathology
Cirrhosis
Kaplan-Meier Estimate
Chronic liver disease
Gastroenterology
lcsh:Chemistry
nonalcoholic steatohepatitis
Phosphorylation
lcsh:QH301-705.5
Spectroscopy
Aged
80 and over
Fatty liver
Liver Neoplasms
p27
General Medicine
hepatocellular carcinoma
Middle Aged
Prognosis
Immunohistochemistry
Computer Science Applications
Hepatocellular carcinoma
Biomarker (medicine)
Female
Cyclin-Dependent Kinase Inhibitor p27
Fatty Liver
Alcoholic
medicine.medical_specialty
Carcinoma
Hepatocellular
Catalysis
Article
Disease-Free Survival
Inorganic Chemistry
Internal medicine
medicine
Carcinoma
Humans
Physical and Theoretical Chemistry
Molecular Biology
Aged
Proportional Hazards Models
business.industry
Organic Chemistry
Cancer
medicine.disease
digestive system diseases
lcsh:Biology (General)
lcsh:QD1-999
Steatohepatitis
business
Transcriptome
Biomarkers
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 14, Iss 12, Pp 23499-23515 (2013)
Volume 14
Issue 12
Pages 23499-23515
ISSN: 1422-0067
Popis: Non-alcoholic steatohepatitis (NASH) is a recently identified chronic liver disease, which progresses to liver cirrhosis and hepatocellular carcinoma (HCC). As the number of patients studied to date has been limited, clinically useful prognostic biomarkers of NASH-related HCC have not been available. In this study, we investigated the status of a cell-cycle regulator, p27, in NASH-related HCC. p27 has been regarded as a prognostic factor in various types of cancer patients. A total of 22 cases with NASH-related HCC were analyzed for p27 protein expression, and phosphorylation at threonine 157 (T157) and serine 10 (S10) by immunohistochemical analysis. The correlation of p27 with tumor characteristics, disease-free survival (DFS), and overall survival was analyzed. p27 expression was decreased in 13 HCCs (59%), and was significantly correlated with enlarged tumor size (p = 0.01) and increased cell proliferation (p <
0.01). Phospho-p27 at T157 and S10 was detected in four (18%) and seven (32%) cases, respectively, and patients positive for phospho-p27 (S10) showed reduced DFS (hazard ratio 7.623, p = 0.016) by univariate analysis. Further studies with more patients are required to verify the usefulness of p27 as a biomarker for predicting tumor recurrence in NASH patients.
Databáze: OpenAIRE
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