Avian influenza A(H5N1) viruses can directly infect and replicate in human gut tissues
| Autor: | Xiao-Ning Xu, Ye Zhang, Ming Wang, Dexin Li, Yuelong Shu, Yu Wang, Jiangfang Zhou, Jie Dong, Qian Liang, Xiao-Ping Dong, Rongbao Gao, Tian Bai, Andrew J. McMichael, Chris Ka-fai Li, Zi Li, Dayan Wang, Libo Dong, Weizhong Yang, Zijian Feng, Hongjie Yu, Le-ying Wen |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Colon
animal diseases Orthomyxoviridae Receptors Cell Surface Virus Replication Organ culture medicine.disease_cause Epithelium Virus Microbiology Organ Culture Techniques Influenza Human medicine Influenza A virus Humans Immunology and Allergy Intestinal Mucosa Gastrointestinal tract Influenza A Virus H5N1 Subtype biology Reverse Transcriptase Polymerase Chain Reaction virus diseases biology.organism_classification Virology Influenza A virus subtype H5N1 Gut Epithelium Infectious Diseases medicine.anatomical_structure Respiratory tract |
| Popis: | The human respiratory tract is a major site of avian influenza A(H5N1) infection. However, many humans infected with H5N1 present with gastrointestinal tract symptoms, suggesting that this may also be a target for the virus. In this study, we demonstrated that the human gut expresses abundant avian H5N1 receptors, is readily infected ex vivo by the H5N1 virus, and produces infectious viral particles in organ culture. An autopsy colonic sample from an H5N1-infected patient showed evidence of viral antigen expression in the gut epithelium. Our results provide the first evidence, to our knowledge, that H5N1 can directly target human gut tissues. |
| Databáze: | OpenAIRE |
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