Bovine Glomerular Amyloidosis: Morphological Studies
| Autor: | Z.-Y. Zhou, G. Husby, K. Nordstoga |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pathology
medicine.medical_specialty Amyloid Glomerular deposits Kidney Glomerulus Cattle Diseases Pathology and Forensic Medicine mental disorders medicine Animals Animal species Serum Amyloid A Protein Avidin biotin complex General Veterinary biology Immunoperoxidase Chemistry Amyloidosis medicine.disease Amyloid fibril Immunohistochemistry Primary and secondary antibodies Microscopy Electron biology.protein Cattle Female Kidney Diseases |
| Zdroj: | Journal of Veterinary Medicine Series A. 41:741-747 |
| ISSN: | 1439-0442 0931-184X |
| DOI: | 10.1111/j.1439-0442.1994.tb00144.x |
| Popis: | Summary Bovine kidney material with advanced glomerular deposits of amyloid was studied immunohistochemically using the avidin biotin complex immunoperoxidase method, with rabbit antihorse AA serum as primary antibody. Severely affected glomeruli consisted of strongly reacting positive material, obscuring all cellular structures. Transmission electron microscopy revealed that the amyloidotic areas, with evident amyloid fibrils, also contained a considerable admixture of cellular remnants. In this investigation it was found that such material was more abundant in the bovine glomerular amyloid masses than in amyloid laden organs from other animal species, and it is discussed to what extent this observation may explain the varying tinctorial properties of amyloid deposits in bovine tissues, and the relative high content of histones in bovine amyloid proteins. |
| Databáze: | OpenAIRE |
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