Pharmacokinetics and efficacy of amoxycillin in the treatment of an experimental Streptococcus bovis infection in racing pigeons (Columba livia)
| Autor: | Kris Baert, P. De Herdt, Jean Paul Remon, P. De Backer, Hubert Vermeersch, J. Soenens, Hans Nelis, Patrick Butaye, Brenda Vermeulen |
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| Rok vydání: | 1998 |
| Předmět: |
Veterinary medicine
General Veterinary biology business.industry Bird Diseases Treatment outcome Amoxicillin Penicillins Streptococcus bovis biology.organism_classification Bioavailability Treatment Outcome Pharmacokinetics Streptococcal Infections polycyclic compounds Medicine Animals Animal Science and Zoology business Columbidae Clearance |
| Zdroj: | Veterinary journal (London, England : 1997). 156(1) |
| ISSN: | 1090-0233 |
| Popis: | The pharmacokinetics of amoxycillin in pigeons (Columba livia) and the efficacy of amoxycillin treatment in pigeon streptococcosis, were investigated. After intravenous administration of 150 mg.kg-1 amoxycillin, the drug plasma concentration-time profile fitted an open two-compartment model. Amoxycillin was quickly cleared from the circulation with a mean half-life of 66 min and showed a distribution volume of 0.9 L.kg-1. The absolute oral bioavailability of amoxycillin was 50.1%. A 5-day drinking water treatment with amoxycillin (1500 mg.L-1, corresponding to 112.0 mg.kg-1.day-1 during day-light hours) significantly reduced the postinoculation morbidity in pigeons experimentally infected with Streptococcus bovis, compared to untreated infected controls. |
| Databáze: | OpenAIRE |
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