A randomized clinical study using optical coherence tomography to evaluate the short-term effects of high-intensity interval training on cardiac allograft vasculopathy: a HITTS substudy

Autor: Kari Nytrøen, Muzammil Rafique, Jouke Dijkstra, Lars Gullestad, Bjørn Bendz, Katrine Rolid, Ole Geir Solberg, Niels Ramsing Holm, Ketil Lunde, Omeed Neghabat
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Clinical Transplantation, 36(1). WILEY
Rafique, M, Solberg, O G, Gullestad, L, Bendz, B, Holm, N R, Neghabat, O, Dijkstra, J, Nytrøen, K, Rolid, K & Lunde, K 2022, ' A randomized clinical study using optical coherence tomography to evaluate the short-term effects of high-intensity interval training on cardiac allograft vasculopathy : a HITTS substudy ', Clinical Transplantation, vol. 36, no. 1, 14488 . https://doi.org/10.1111/ctr.14488
ISSN: 0902-0063
Popis: Cardiac allograft vasculopathy (CAV) remains a leading cause of long-term mortality after heart transplantation. Both preventive measures and treatment options are limited. This study aimed to evaluate the short-term effects of high-intensity interval training (HIT) on CAV in de novo heart transplant (HTx) recipients as assessed by optical coherence tomography (OCT). The study population was a subgroup of the 81-patient HITTS study in which HTx recipients were randomized to HIT or moderate intensity continuous training (MICT) for nine consecutive months. OCT images from baseline and 12 months were compared to assess CAV progression. The primary endpoint was defined as the change in the mean intima area. Paired OCT data were available for 56 patients (n = 23 in the HIT group and n = 33 in the MICT group). The intima area in the entire study population increased by 25% [from 1.8±1.4mm2 to 2.3±2.0mm2 , p
Databáze: OpenAIRE
Externí odkaz: