Age and Brain Catecholamine Content as Factors Influencing Amphetamine Toxicity in Mice
| Autor: | Erik Klinge, Eeva Alhava |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Dopamine Mice Inbred Strains Stimulation Toxicology 030226 pharmacology & pharmacy Mice Norepinephrine 03 medical and health sciences 0302 clinical medicine Age groups Internal medicine medicine Animals Drug Interactions Norepinephrine metabolism Amphetamine Dopamine metabolism 030304 developmental biology Pharmacology 0303 health sciences Chemistry Age Factors Brain Stimulation Chemical 3. Good health Endocrinology Depression Chemical Toxicity Catecholamine Female medicine.drug |
| Zdroj: | Acta Pharmacologica et Toxicologica. 31:401-411 |
| ISSN: | 0001-6683 |
| DOI: | 10.1111/j.1600-0773.1972.tb03603.x |
| Popis: | The brain noradrenaline (NA) and dopamine (DA) content of adult and developing mice of 3 age groups (3–5, 13–15 and 32–35 days) was assayed and found to increase with age. In adult mice 4 hrs after the administration of 50 mg/kg of amphetamine the brain NA content was decreased by 65 %. After 100 mg/kg of amphetamine the mice died in 25 min., but the NA and DA levels were only slightly decreased. In all age groups of developing mice, the doses of amphetamine sufficient to be lethal in 30 min. (100–160 mg/kg) caused only a slight decrease or even an increase in brain NA and DA levels. In developing mice surviving 60 min. after amphetamine, the brain amines were massively depleted. In adult mice the brain NA content in 1 hr and 4 hrs after the pretreatment dose of 5 mg/kg of amphetamine decreased by 20 %. The dose of 60 mg/kg 4 hrs after the pretreatment caused a massive depletion in brain NA and DA content 1 hr after the latter injection. Even though the mice survived. The lack of correlation between brain catecholamine depletion and amphetamine toxicity reflects the complex lethal mechanisms induced by the drug. |
| Databáze: | OpenAIRE |
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