Prognostic Factors and Adjuvant Treatments for Surgically Treated Cancers of the Biliary Tract: A Multicentre Study of the Anatolian Society of Medical Oncology (ASMO)
| Autor: | Onder Tonyali, Tugba Kos, Bilge Aktas, Umut Demirci, Ahmet Yilmaz, Alper Sevinc, Ilhan Oztop, Kaan Helvaci, Havva Yesil Cinkir, Ozan Balakan, Ramazan Yildiz, Assoc, Veli Berk, Mehmet Kucukoner, Nedim Turan, Olcun Umit Unal |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Epidemiology Perineural invasion Deoxycytidine Young Adult Internal medicine Antineoplastic Combined Chemotherapy Protocols Humans Medicine Neoplasm Invasiveness Survival rate Lymph node Aged Neoplasm Staging Retrospective Studies Aged 80 and over Univariate analysis Biliary tract neoplasm business.industry Standard treatment Public Health Environmental and Occupational Health Chemoradiotherapy Adjuvant Middle Aged Prognosis Combined Modality Therapy Gemcitabine Survival Rate Biliary Tract Neoplasms medicine.anatomical_structure Female Fluorouracil Cisplatin business Chemoradiotherapy Follow-Up Studies medicine.drug |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 15:9687-9692 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2014.15.22.9687 |
| Popis: | Background: Biliary tract cancers are rare, and surgical resection is the standard treatment at early stages. However, reports on the benefits of adjuvant treatment following surgical resection are conflicting. This study aimed to evaluate the factors affecting survival and adjuvant treatments in patients with surgically treated biliary tract cancers. Materials and Methods: Patient clinical features, adjuvant treatments, and efficacy and prognostic factor data were evaluated. Survival analyses were performed using SPSS 15.0. Results: The median overall survival was 30.7 months (95% confidence interval [CI], 18.4-42.9 months). Median survival was 19 months (95% CI, 6-33) for patients treated with fluorouracil based chemotherapy and 53 months (95% CI, 33.2-78.8) with gemcitabine based chemotherapy (p=0.033). On univariate analysis, poor prognostic factors for survival were galbladder localization, perineural invasion, hepatic invasion, a lack of adjuvant chemoradiotherapy treatment, and a lack of lymph node dissection. On multivariate analysis, perineural invasion was a poor prognostic factor (p=0.008). Conclusions: Biliary tract cancers generally have poor prognoses. The main factors affecting survival are tumour localization, perineural invasion, hepatic invasion, adjuvant chemoradiotherapy, and lymph node dissection. Gemcitabine-based adjuvant chemotherapy is more effective than 5-fluorouracil-based chemotherapy. |
| Databáze: | OpenAIRE |
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