Dietary compliance in a randomized double‐blind infant feeding trial during infancy aiming at prevention of type 1 diabetes

Autor: Suvi M. Virtanen, David Cuthbertson, Anita M. Nucci, Mila Hyytinen, Anne Ormisson, Marja Salonen, Tania Turrini, Elizabeth A. Cummings, Brenda Bradley, Marilyn Tanner‐Blasiar, Dorothy J. Becker, Hans K. Åkerblom, Erkki Savilahti, Jeffrey P. Krischer, Mikael Knip, the TRIGR Investigators
Přispěvatelé: Research Services, HUS Children and Adolescents, Children's Hospital, University of Helsinki, Clinicum, Lastentautien yksikkö, Tampere University, Health Sciences, Department of Paediatrics, Tays Research Services
Rok vydání: 2021
Předmět:
Allergy
Pediatrics
medicine.medical_specialty
infant feeding
type 1 diabetes
Dietary compliance
Population
030209 endocrinology & metabolism
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
3123 Gynaecology and paediatrics
law
Casein
PROGRAM
research methodology
Medicine
TX341-641
030212 general & internal medicine
education
Infant feeding
Original Research
RISK
2. Zero hunger
FORMULA
education.field_of_study
Type 1 diabetes
infant and child nutrition
Nutrition. Foods and food supply
business.industry
nutritional interventions
infant formula
COWS MILK
medicine.disease
3142 Public health care science
environmental and occupational health
3. Good health
3141 Health care science
ALLERGY
Infant formula
randomized controlled trial
BETA-CELL AUTOIMMUNITY
business
INTERVENTION
Food Science
Zdroj: Food Science & Nutrition, Vol 9, Iss 8, Pp 4221-4231 (2021)
Food Science & Nutrition
ISSN: 2048-7177
DOI: 10.1002/fsn3.2389
Popis: The international Trial to Reduce IDDM in the Genetically at Risk (TRIGR) tested the hypothesis whether extensively hydrolyzed casein‐based versus regular cow's milk‐based infant formula reduces the risk of type 1 diabetes. We describe dietary compliance in the trial in terms of study formula intake, feeding of nonrecommended foods, and serum cow's milk antibody concentration reflecting intake of cow's milk protein among 2,159 eligible newborn infants with a biological first‐degree relative affected by type 1 diabetes and with HLA‐conferred susceptibility to type 1 diabetes. The participating infants were introduced to the study formula feeding at the median age of 15 days with a median duration of study formula use of 63 days. During the intervention, 80% of the infants received study formula. Of these, 57% received study formula for at least 2 months. On average, 45.5 l of study formula were used per infant. Only 13% of the population had received a nonrecommended food by the age of 6 months. The dietary compliance was similar in the intervention and control arm. The reported cow's milk consumption by the families matched very well with measured serum casein IgA and IgG antibody concentration. To conclude, good compliance was observed in this randomized infant feeding trial. Compliance varied between the regions and those infants who were breastfed for a longer period of time had a shorter exposure to the study formula. High dietary compliance in infant feeding trial is necessary to allow accurate interpretation of study results.
The international Trial to Reduce IDDM in the Genetically at Risk (TRIGR) tested the hypothesis whether extensively hydrolyzed casein‐based versus regular cow's milk‐based infant formula reduces the risk of type 1 diabetes. We describe good dietary compliance in the trial in terms of study formula feeding, feeding of non‐recommended foods, and serum cow's milk antibody concentration reflecting intake of cow's milk protein among 2,159 eligible newborn infants with a biological first degree relative affected by type 1 diabetes and with HLA‐conferred susceptibility to type 1 diabetes.
Databáze: OpenAIRE
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