miR-938 promotes cell proliferation by regulating RBM5 in lung adenocarcinoma cells
| Autor: | Taotao Qian, Lincen Xie, Shunbin Shi, Yong Zhu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Lung Tumor size Cell growth In vitro toxicology Cell Biology General Medicine Biology medicine.disease Tumor tissue 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Cell culture 030220 oncology & carcinogenesis microRNA medicine Cancer research Adenocarcinoma |
| Zdroj: | Cell biology international. |
| ISSN: | 1095-8355 |
| Popis: | A growing body of research suggests that microRNAs (miRNAs) may play a key part in the progression of various cancers, including lung adenocarcinoma (LUAD). However, the expression and mechanism of miR-938 (microRNA-938) in LUAD have not been defined. Compared with adjacent tissues, the level of miR-938 was up-regulated in LUAD tissues. miR-938 expression was significantly associated with tumor size. In vitro assays indicated that miR-938 expression was also increased in the LUAD cell lines. Overexpression of miR-938 promoted LUAD cell proliferation, whereas down-regulation of miR-938 had the opposite effect. We identified RNA-binding protein 5 (RBM5) as a potential target gene of miR-938 in LUAD. Expression of RBM5 was down-regulated in LUAD tumor tissues and negatively correlated with expression of miR-938. Up-regulation of RBM5 reversed cell proliferation by inhibition of miR-938 expression in LUAD cells. These results showed that miR-938 may act as an oncogenic miRNA by targeting RBM5 in LUAD, indicating that miR-938 could be used as a potential therapeutic target for LUAD patients. |
| Databáze: | OpenAIRE |
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