Vesicle Origami: Cuboid Phospholipid Vesicles Formed by Template-Free Self-Assembly
| Autor: | Sandor Balog, Andreas Zumbuehl, Radu Tanasescu, Takashi Ishikawa, Frederik Neuhaus, Gerald Brezesinski, Dennis Mueller |
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| Rok vydání: | 2017 |
| Předmět: |
Liposome
Cuboid Lateral surface Chemistry Bilayer Vesicle General Medicine 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Catalysis 0104 chemical sciences 3. Good health Surface tension Crystallography Membrane Chemical physics ddc:540 Self-assembly 0210 nano-technology |
| Zdroj: | Angewandte Chemie / International edition 56(23), 6515-6518 (2017). doi:10.1002/anie.201701634 |
| ISSN: | 1433-7851 |
| Popis: | Phospholipid liposomes are archetypical self-assembled structures. To minimize the surface tension, the vesicles typically are spherical. Deciphering the bilayer code, the basic physical interactions between phospholipids would allow these molecules to be utilized as building blocks for novel, non-spherical structures. A 1,2-diamidophospholipid is presented that self-assembles into a cuboid structure. Owing to intermolecular hydrogen bonding, the bilayer membranes form an exceptionally tight subgel packing, leading to a maximization of flat structural elements and a minimization of any edges. These conditions are optimized in the geometrical structure of a cube. Surprisingly, the lateral surface pressure in the membrane is only one third of the value typically assumed for a bilayer membrane, questioning a long-standing rule-of-thumb. |
| Databáze: | OpenAIRE |
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