Recommendations for the categorization of germ cell mutagens
| Autor: | Ricarda Thier, P. Kreis, D. Wild, Hans-Günter Neumann, I.-D. Adler, U. Andrae |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Genetics
endocrine system Mutation Somatic cell fungi Public Health Environmental and Occupational Health food and beverages Chromosome Mutagen Gene mutation Biology medicine.disease_cause Germ Cells medicine.anatomical_structure Risk Factors medicine Humans Germ Germ-Line Mutation Germ cell Genotoxicity Mutagens |
| Zdroj: | International Archives of Occupational and Environmental Health. 73:428-432 |
| ISSN: | 1432-1246 0340-0131 |
| DOI: | 10.1007/s004200000122 |
| Popis: | Germ cell mutagens are currently classified into three categories in the German List of MAK and BAT Values. These categories have been revised and extended by analogy with the new categories for carcinogenic chemicals. Germ cell mutagens produce heritable gene mutations, and heritable structural and numerical chromosome aberrations in germ cells. The original categories 1 and 2 for germ cell mutagens remain unchanged. Two new categories 3A and 3B are proposed for chemicals suspected to be germ cell mutagens. A new category 5 is proposed for germ cell mutagens with low potency that contribute negligibly to human genetic risk provided the MAK value is observed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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