Impaired glucose metabolism in patients with diabetes, prediabetes and obesity is associated with severe Covid‐19
| Autor: | Ruth I Connor, Stephen M. Smith, David P. Dobesh, Kathy Chao, Enrique Unson, Daniel A. Maddock, Julie A. Traupman, Avinash Boppana, Adam Brufsky |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty obesity Aging Carbohydrate metabolism Gastroenterology SARS‐CoV‐2 Body Mass Index Pathogenesis Diabetes Complications Prediabetic State 03 medical and health sciences Young Adult 0302 clinical medicine Glucose Metabolism Disorder COVID‐19 glucose metabolism disorder Virology Internal medicine Diabetes mellitus medicine Humans 030212 general & internal medicine Prediabetes Young adult Research Articles Aged Aged 80 and over Glycated Hemoglobin business.industry SARS-CoV-2 COVID-19 Middle Aged medicine.disease Obesity Infectious Diseases Glucose diabetes mellitus 030211 gastroenterology & hepatology Female hyperglycemia business Body mass index Research Article |
| Zdroj: | Journal of Medical Virology |
| ISSN: | 1096-9071 0146-6615 |
| Popis: | BACKGROUND: Identification of risk factors of severe coronavirus disease 2019 (COVID-19) is critical for improving therapies and understanding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. We analyzed 184 patients hospitalized for COVID-19 in Livingston, New Jersey for clinical characteristics associated with severe disease. The majority of patients with COVID-19 had diabetes mellitus (DM) (62.0%), Pre-DM (23.9%) with elevated fasting blood glucose (FBG), or a body mass index >30 with normal hemoglobin A1c (HbA1C) (4.3%). SARS-CoV-2 infection was associated with new and persistent hyperglycemia in 29 patients, including several with normal HbA1C levels. Forty-four patients required intubation, which occurred significantly more often in patients with DM as compared with non-diabetics. Severe COVID-19 occurs in the presence of impaired glucose metabolism in patients, including those with DM, preDM, and obesity. COVID-19 is associated with elevated FBG and several patients presented with new onset DM or in DKA. The association of dysregulated glucose metabolism and severe COVID-19 suggests that SARS-CoV-2 pathogenesis involves a novel interplay with glucose metabolism. Exploration of pathways by which SARS-CoV-2 interacts glucose metabolism is critical for understanding disease pathogenesis and developing therapies. |
| Databáze: | OpenAIRE |
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