Sex differences in brain metabolite concentrations in healthy children – proton magnetic resonance spectroscopy study ( 1 HMRS)
| Autor: | Cichocka, Monika, Kozub, Justyna, Karcz, Paulina, Urbanik, Andrzej |
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| Rok vydání: | 2018 |
| Předmět: |
sex differences
0301 basic medicine Cerebellum Volume of interest business.industry brain Metabolite Physiology proton magnetic resonance spectroscopy (1HMRS) Proton magnetic resonance Clinical Practice 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure children chemistry Basal ganglia Medicine Statistical analysis business 030217 neurology & neurosurgery |
| Zdroj: | Polish Journal of Radiology. 83:24-31 |
| ISSN: | 1899-0967 |
| DOI: | 10.5114/pjr.2018.74536 |
| Popis: | Purpose: The aim of this 1HMRS study was to define sex-related differences in metabolic spectrum between healthy children. Forty-nine girls and boys aged 6-15 years were examined. Material and methods: Volume of interest was located in seven brain regions: frontal lobes, basal ganglia, hippocampi, and cerebellum. Results: Statistical analysis of the results showed significantly higher (p < 0.05) myo-inositol concentrations relative to the total concentrations in the boys than the girls, as well as higher absolute N-acetyl aspartate concentrations in the left frontal lobes in girls. No other significant differences were shown, except for trends in differences. Conclusions: In clinical practice the diagnostic process first of all focuses on assessing concentrations of metabolites to relative cerebellum concentration. Thus, the findings of the present study allow the conclusion that when analysing the results of 1HMRS studies in children it is not necessary to take into account the child's gender. |
| Databáze: | OpenAIRE |
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