The Modulatory Effect of Motor Cortex Astrocytes on Diabetic Neuropathic Pain
| Autor: | Huoshu Chen, Fangfang Xiong, Xiongbin Yan, Ji-Yuan Liu, Chang-Xi Yu, Li Chen, Hui-Hui Huang, Jing-Shan Lu, Li-Huan Hu, Lijing Ai, Jian Chen, Lan Yang, Ying Xu |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine chemical and pharmacologic phenomena Selective inhibition Diabetes Mellitus Experimental Rats Sprague-Dawley Pathogenesis 03 medical and health sciences 0302 clinical medicine Diabetic Neuropathies Animals Medicine Receptor Research Articles business.industry General Neuroscience Motor Cortex Nociceptive processing Streptozocin 030104 developmental biology medicine.anatomical_structure Cerebral cortex Astrocytes Neuropathic pain Neuralgia business Neuroscience 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | J Neurosci |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.2566-20.2021 |
| Popis: | Diabetic neuropathic pain (DNP) is a common complication of diabetes characterized by persistent pain. Emerging evidence links astrocytes to mechanical nociceptive processing, and the motor cortex (MCx) is a cerebral cortex region that is known to play a key role in pain regulation. However, the association between MCx astrocytes and DNP pathogenesis remains largely unexplored. Here, we studied this association using designer receptors exclusively activated by designer drugs to specifically manipulate MCx astrocytes. We proved that the selective inhibition of MCx astrocytes reduced DNP in streptozocin (STZ)-induced DNP models and discovered a potential mechanism by which astrocytes release cytokines, including TNF-α and IL-1β, to increase neuronal activation in the MCx, thereby regulating pain. Together, these results demonstrate a pivotal role for MCx astrocytes in DNP pathogenesis and provide new insight into DNP treatment strategies. |
| Databáze: | OpenAIRE |
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