Catalytic Asymmetric Bromocyclization of Polyenes
| Autor: | Hisashi Yamamoto, Ramesh C. Samanta |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Bromine
010405 organic chemistry chemistry.chemical_element General Chemistry 010402 general chemistry Polyene 01 natural sciences Biochemistry Catalysis 0104 chemical sciences chemistry.chemical_compound Colloid and Surface Chemistry chemistry Electrophile Organic chemistry Enantiomer Thiophosphoramide |
| Zdroj: | Journal of the American Chemical Society. 139:1460-1463 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.6b13193 |
| Popis: | The first catalytic asymmetric bromonium ion-induced polyene cyclization has been achieved by using a chiral BINOL-derived thiophosphoramide catalyst and 1,3-dibromo-5,5-dimethylhydantoin as an electrophilic bromine source. Bromocyclization products are obtained in high yields, with good enantiomeric ratios and high diastereoselectivity, and are abundantly found as scaffolds in natural products. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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