Imaging of Substantia Nigra in Parkinson's Disease: A Narrative Review
| Autor: | Roberta Baschi, Massimo Midiri, Paola Feraco, Giuseppe La Tona, Maria Chiara Malaguti, Benedetto Petralia, Laura Geraci, Eleonora Bruno, Anna Del Poggio, Cesare Gagliardo, Roberto Monastero, Costanza D'Angelo, Maurizio Marrale |
|---|---|
| Přispěvatelé: | Feraco, Paola, Gagliardo, Cesare, La Tona, Giuseppe, Bruno, Eleonora, D’angelo, Costanza, Marrale, Maurizio, Del Poggio, Anna, Malaguti, Maria Chiara, Geraci, Laura, Baschi, Roberta, Petralia, Benedetto, Midiri, Massimo, Monastero, Roberto, Feraco P., Gagliardo C., La Tona G., Bruno E., D'angelo C., Marrale M., Del Poggio A., Malaguti M.C., Geraci L., Baschi R., Petralia B., Midiri M., Monastero R. |
| Rok vydání: | 2021 |
| Předmět: |
Parkinson's disease
Settore MED/50 - Scienze Tecniche Mediche Applicate Substantia nigra Neurosciences. Biological psychiatry. Neuropsychiatry Disease Striatum Review 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine iron neurodegenerative disease medicine magnetic resonance imaging neurodegenerative diseases medicine.diagnostic_test Pars compacta business.industry General Neuroscience radiomic Settore MED/37 - Neuroradiologia biomarkers Magnetic resonance imaging medicine.disease parkinsonian disorders nigrosome-1 radiomics Parkinson’s disease biomarker Settore MED/26 - Neurologia Differential diagnosis neuromelanin business Settore MED/36 - Diagnostica Per Immagini E Radioterapia Neuroscience 030217 neurology & neurosurgery Diffusion MRI RC321-571 |
| Zdroj: | Brain Sciences Brain Sciences, Vol 11, Iss 769, p 769 (2021) |
| ISSN: | 2076-3425 |
| Popis: | Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by motor and non-motor symptoms due to the degeneration of the pars compacta of the substantia nigra (SNc) with dopaminergic denervation of the striatum. Although the diagnosis of PD is principally based on a clinical assessment, great efforts have been expended over the past two decades to evaluate reliable biomarkers for PD. Among these biomarkers, magnetic resonance imaging (MRI)-based biomarkers may play a key role. Conventional MRI sequences are considered by many in the field to have low sensitivity, while advanced pulse sequences and ultra-high-field MRI techniques have brought many advantages, particularly regarding the study of brainstem and subcortical structures. Nowadays, nigrosome imaging, neuromelanine-sensitive sequences, iron-sensitive sequences, and advanced diffusion weighted imaging techniques afford new insights to the non-invasive study of the SNc. The use of these imaging methods, alone or in combination, may also help to discriminate PD patients from control patients, in addition to discriminating atypical parkinsonian syndromes (PS). A total of 92 articles were identified from an extensive review of the literature on PubMed in order to ascertain the-state-of-the-art of MRI techniques, as applied to the study of SNc in PD patients, as well as their potential future applications as imaging biomarkers of disease. Whilst none of these MRI-imaging biomarkers could be successfully validated for routine clinical practice, in achieving high levels of accuracy and reproducibility in the diagnosis of PD, a multimodal MRI-PD protocol may assist neuroradiologists and clinicians in the early and differential diagnosis of a wide spectrum of neurodegenerative disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|