Neuroprotective Effect of Resveratrol on Acute Brain Ischemia Reperfusion Injury by Measuring Annexin V, p53, Bcl-2 Levels in Rats
| Autor: | Ceren Kizmazoglu, Nurullah Yuceer, Orhan Kalemci, Ismail Ertan Sevin, Metin Ant Atasoy, Hasan Emre Aydin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
p53
Pathology medicine.medical_specialty Ischemia Pharmacology Resveratrol Annexin V Brain Ischemia Brain ischemia chemistry.chemical_compound Annexin Medicine Bcl-2 business.industry Cerebral infarction General Neuroscience medicine.disease Cerebral blood flow chemistry Apoptosis Laboratory Investigation Surgery Neurology (clinical) business Reperfusion injury |
| Zdroj: | Journal of Korean Neurosurgical Society |
| ISSN: | 1598-7876 2005-3711 |
| Popis: | Background : Cerebral ischemia is as a result of insufficient cerebral blood flow for cerebral metabolic functions. Resveratrol is a natural phytoalex in that can be extracted from grape’s skin and had potent role in treating the cerebral ischemia. Apoptosis, a genetically programmed cellular event which occurs after ischemia and leads to biochemical and morphological changes in cells. There are some useful markers for apoptosis like Bcl-2, bax, and p53. The last reports, researchers verify the apoptosis with early markers like Annexin V. Methods : We preferred in this experimental study a model of global cerebral infarction which was induced by bilateral common carotid artery occlusion method. Rats were randomly divided into 4 groups : sham, ischemia-reperfusion (I/R), I/R plus 20 mg/kg resveratrol and I/R plus 40 mg/kg resveratrol. Statistical analysis was performed using Sigmastat 3.5 ve IBM SPSS Statistics 20. We considered a result significant when p |
| Databáze: | OpenAIRE |
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