Intralesional bleomycin-mediated electrochemotherapy in 20 patients with basal cell carcinoma
| Autor: | Glass Lf, Douglas S. Reintgen, Mark J. Jaroszeski, Richard Gilbert, Richard Heller |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Antimetabolites Antineoplastic Pathology medicine.medical_specialty Electrochemotherapy Cell Membrane Permeability Skin Neoplasms medicine.medical_treatment Dermatology Injections Intralesional Bleomycin Cicatrix chemistry.chemical_compound Skin Ulcer medicine Carcinoma Humans Basal cell carcinoma Aged Wound Healing Chemotherapy Antibiotics Antineoplastic business.industry Electroporation Remission Induction Bleomycin Sulfate Iontophoresis Middle Aged Stainless Steel medicine.disease Electrodes Implanted chemistry Carcinoma Basal Cell Erythema Needles Cancer research Neoplasm Recurrence Local business Wound healing Follow-Up Studies |
| Zdroj: | Journal of the American Academy of Dermatology. 37:596-599 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/s0190-9622(97)70178-6 |
| Popis: | Background: A new anticancer therapy, electrochemotherapy (ECT), has been introduced that entails exposing cancerous tissues to short pulses of electricity during chemotherapy. This enhances cell membrane permeability and has been shown to have potent antitumor effects in vitro in animal models and in several clinical trials, including nevoid basal cell carcinoma (BCC). Objective: We report the effects of ECT on 20 patients with primary BCC. Methods: Electrical pulses were delivered to 54 tumors after administration of intralesional bleomycin sulfate. Results: Complete responses were observed in 53 (98%), and in the majority of these (94%) after a single treatment. No recurrences have been recorded with a mean of 18 months of observation. Conclusion: Although these are preliminary results, ECT appears to be an effective alternative to surgical excision for the treatment of primary BCC. (J Am Acad Dermatol 1997;37:596-9.) |
| Databáze: | OpenAIRE |
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