Dynemicins O, P and Q: novel antibiotics related to dynemicin A isolation, characterization and biological activity
| Autor: | Naoko Morisaki, Toshikazu Oki, Yoshiyuki Tokiwa, Shigeo Iwasaki, Kyoichiro Saitoh, Masataka Konishi, Megumi Miyoshi-Saitoh |
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| Rok vydání: | 1991 |
| Předmět: |
Dynemicin A
Magnetic Resonance Spectroscopy Stereochemistry Ethyl acetate Epoxide Anthraquinones Microbial Sensitivity Tests Alkenes Micromonospora chemistry.chemical_compound Mice Phenylene Drug Discovery Tumor Cells Cultured Animals Humans Pharmacology Chromatography Antibiotics Antineoplastic biology Bacteria Spectrum Analysis Biological activity biology.organism_classification Anti-Bacterial Agents chemistry Actinomycetales Drug Screening Assays Antitumor Enediynes |
| Zdroj: | The Journal of antibiotics. 44(10) |
| ISSN: | 0021-8820 |
| Popis: | New antibiotics, dynemicins O (3), P (4) and Q (5), were isolated from the culture broth of Micromonospora chersina M956-1, the dynemicin A (1)-producing strain. An ethyl acetate extract of a tank culture was roughly separated by a column of Diaion SP-800 and was further purified by combining a variety of column chromatographies to afford a few mg of compounds 3, 4 and 5. Their structures, analyzed from the spectral data, had a bridging phenylene group, a vic-diol and an oxo group in place of the respective 1,5-diyn-3-ene bridge, the epoxide ring and the carboxyl group in dynemicin A. Their biological activities were evaluated against bacteria and tumor cells. |
| Databáze: | OpenAIRE |
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