Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs
| Autor: | Seiji Kurozumi, Takeshi Tsuka, Kazuo Azuma, Tomohiro Imagawa, Tomohiro Osaki, Yoshiharu Okamoto, Yoshimori Takamori, Saburo Minami |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Hydrochloride Pharmaceutical Science Administration Oral Biology Article chemistry.chemical_compound Dogs metabolomic analyses Fumarates Oral administration Glucosamine Internal medicine Drug Discovery Blood plasma Respiration medicine Animals Metabolomics Regeneration Anaerobiosis Lactic Acid Amino Acids Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 chemistry.chemical_classification Alanine Amino acid Lactic acid carbohydrates (lipids) amino acid dog glucosamine hydrochloride Endocrinology Cartilage chemistry lcsh:Biology (General) |
| Zdroj: | Marine Drugs Marine Drugs; Volume 10; Issue 8; Pages: 1873-1882 Marine Drugs, Vol 10, Iss 8, Pp 1873-1882 (2012) |
| ISSN: | 1660-3397 |
| Popis: | D-Glucosamine hydrochloride (GlcN∙HCl) is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals. The aim of this study was to examine amino acid metabolism in dogs after oral administration of GlcN∙HCl. Accelerated fumarate respiration and elevated plasma levels of lactic acid and alanine were observed after administration. These results suggest that oral administration of GlcN∙HCl induces anaerobic respiration and starvation in cells, and we hypothesize that these conditions promote cartilage regeneration. Further studies are required to evaluate the expression of transforming growth factor-beta (TGF-β). |
| Databáze: | OpenAIRE |
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