Molecular characterization of aromatase
| Autor: | Yanyan Hong, Yate-Ching Yuan, Hongzhi Li, Shiuan Chen |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
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Molecular medicine.medical_specialty medicine.drug_class Breast Neoplasms Biology Reductase General Biochemistry Genetics and Molecular Biology Article Structure-Activity Relationship Breast cancer Aromatase History and Philosophy of Science Cytochrome P-450 Enzyme System Internal medicine medicine Structure–activity relationship Humans Estrogen synthesis chemistry.chemical_classification General Neuroscience Estrogens medicine.disease Cytochrome P450 Family Enzyme Endocrinology chemistry Estrogen biology.protein Androgens Sequence Alignment Protein Binding |
| Popis: | Aromatase is an estrogen synthetase. Estrogens are female sex hormones involved in the development and growth of breast tumors. It has been of significant interest to elucidate the structure-function relationship of aromatase since its inhibitors have shown great promise in fighting breast cancer. Aromatase belongs to the cytochrome P450 family, and forms an electron-transfer complex with its partner, NADPH-cytochrome P450 reductase. Because of the membrane-bound character and heme-binding instability, no crystal structure of aromatase has been reported so far. Much remains to be investigated, including the 3-dimensional structure of aromatase, interaction between aromatase and reductase, catalytic mechanism of estrogen synthesis by aromatase, and the binding mechanism of aromatase inhibitors. This review will present current knowledge about structural and functional characteristics of aromatase to address unsolved mysteries about this enzyme. |
| Databáze: | OpenAIRE |
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