A Fourier transform infrared spectroscopic and solid-state NMR study of bone mineral in osteogenesis imperfecta
| Autor: | Barrie Pj, N. Garrington, John Cassella, Ali Sy |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Molar Magnetic Resonance Spectroscopy Adolescent Bone density Endocrinology Diabetes and Metabolism Mineralogy Bone and Bones symbols.namesake Endocrinology Nuclear magnetic resonance Bone Density Spectroscopy Fourier Transform Infrared medicine Humans Orthopedics and Sports Medicine Fourier transform infrared spectroscopy Bone mineral Chemistry General Medicine Nuclear magnetic resonance spectroscopy Osteogenesis Imperfecta medicine.disease Fourier transform Solid-state nuclear magnetic resonance Osteogenesis imperfecta symbols Female Phosphorus Radioisotopes |
| Zdroj: | Journal of Bone and Mineral Metabolism. 18:291-296 |
| ISSN: | 0914-8779 |
| DOI: | 10.1007/pl00010645 |
| Popis: | Fourier transform infrared spectroscopy and 31P solid-state nuclear magnetic resonance spectroscopy were used to determine if any structural or compositional differences in osteogenesis imperfecta (OI) bone mineral could be detected that might help to explain the bone fragility observed in this disease. A previous study by Cassella et al. used an electron probe X-ray microanalytical technique to compare the calcium to phosphorus (Ca/P) molar ratios in normal bone and bone from patients with OI. It was demonstrated that bone from OI patients had a lower Ca/P molar ratio. This study demonstrated that OI bone mineral had a general hydroxyapatite structure and that isomorphous substitutions in the carbanoapatite lattice could account for the low Ca/P molar ratio. |
| Databáze: | OpenAIRE |
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