International collaborative study to assess cardiovascular risk and evaluate long‐term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats: The REVEAL Study

Autor: Carmel T. Mooney, Masami Uechi, Remo G. Lobetti, Geoffrey Culshaw, Seung Woo Jung, Denise Saretta Schwartz, Jens Häggström, Jonathan A. Abbott, Victoria Yukie Tachika Ohara, Deborah M. Fine-Ferreira, Janice M. Bright, Dan G. Ohad, Sonya G. Gordon, Yoko Fujii, Valérie Chetboul, Romain Pariaut, Virginia Luis Fuentes, Alison A. Motsinger-Reif, A. Tamborini, Emilie Trehiou-Sechi, Maribeth J. Bossbaly, Jenifer Lunney Brayley, Jessie Rose Payne, Nicole Van Israël, John E. Rush, Christophe Amberger, Wendy A. Ware, Christopher D. Stauthammer, Daniel F. Hogan, Ferenc Manczur, Etienne Côté, Paola Brambilla, Pamela M. Lee, Sabine Riesen, Bruce W. Keene, Kenneth E. Lamb, Barret J. Bulmer, C. Quintavalla, Roberto A. Santilli, Philip R. Fox, Yong Wei Hung, Karsten A. Schober, Rebecca L. Stepien, María Josefa Fernández del Palacio, Marie de Swarte, Nadine Quick, Christina M. Bové, N. Sydney Moïse, Michael B. Lesser, M. Borgarelli, Mark A. Oyama, Manreet K. Singh, Amara H. Estrada, Andrea Vollmar, Claudio Bussadori, Reid K. Nakamura, Andrey Komolov, Gerhard Wess
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
GATOS
medicine.medical_specialty
040301 veterinary sciences
Cardiomyopathy
Cardiology
Standard Article
030204 cardiovascular system & hematology
Cat Diseases
survival
0403 veterinary science
03 medical and health sciences
Heart disorder
0302 clinical medicine
Risk Factors
Internal medicine
Epidemiology
medicine
Animals
asymptomatic
arterial thromboembolism
Survival analysis
Retrospective Studies
General Veterinary
Errata
business.industry
Hypertrophic cardiomyopathy
Age Factors
Retrospective cohort study
04 agricultural and veterinary sciences
Cardiomyopathy
Hypertrophic
medicine.disease
Survival Analysis
Standard Articles
congestive heart failure
Cardiovascular Diseases
Echocardiography
Heart failure
Case-Control Studies
Cats
incidence
outcome
Female
epidemiology
SMALL ANIMAL
business
Cohort study
Zdroj: Journal of Veterinary Internal Medicine
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Fox, P R, Keene, B W, Lamb, K, Schober, K A, Chetboul, V, Luis Fuentes, V, Wess, G, Payne, J R, Hogan, D F, Motsinger-Reif, A, Häggström, J, Trehiou-Sechi, E, Fine-Ferreira, D M, Nakamura, R K, Lee, P M, Singh, M K, Ware, W A, Abbott, J A, Culshaw, G, Riesen, S, Borgarelli, M, Lesser, M B, Van Israël, N, Côté, E, Rush, J E, Bulmer, B, Santilli, R A, Vollmar, A C, Bossbaly, M J, Quick, N, Bussadori, C, Bright, J M, Estrada, A H, Ohad, D G, Fernández-Del Palacio, M J, Lunney Brayley, J, Schwartz, D S, Bové, C M, Gordon, S G, Jung, S W, Brambilla, P, Moïse, N S, Stauthammer, C D, Stepien, R L, Quintavalla, C, Amberger, C, Manczur, F, Hung, Y-W, Lobetti, R, De Swarte, M, Tamborini, A, Mooney, C T, Oyama, M A, Komolov, A, Fujii, Y, Pariaut, R, Uechi, M & Tachika Ohara, V Y 2018, ' International collaborative study to assess cardiovascular risk and evaluate long-term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats : The REVEAL Study ', Journal of Veterinary Internal Medicine, vol. 32, no. 3, pp. 930-943 . https://doi.org/10.1111/jvim.15122
JOURNAL OF VETERINARY INTERNAL MEDICINE
ISSN: 1939-1676
0891-6640
Popis: BACKGROUND: Hypertrophic cardiomyopathy is the most prevalent heart disorder in cats and principal cause of cardiovascular morbidity and mortality. Yet, the impact of preclinical disease is unresolved.HYPOTHESIS/OBJECTIVES: Observational study to characterize cardiovascular morbidity and survival in cats with preclinical nonobstructive (HCM) and obstructive (HOCM) hypertrophic cardiomyopathy and in apparently healthy cats (AH).ANIMALS: One thousand seven hundred and thirty client-owned cats (430 preclinical HCM; 578 preclinical HOCM; 722 AH).METHODS: Retrospective multicenter, longitudinal, cohort study. Cats from 21 countries were followed through medical record review and owner or referring veterinarian interviews. Data were analyzed to compare long-term outcomes, incidence, and risk for congestive heart failure (CHF), arterial thromboembolism (ATE), and cardiovascular death.RESULTS: During the study period, CHF, ATE, or both occurred in 30.5% and cardiovascular death in 27.9% of 1008 HCM/HOCM cats. Risk assessed at 1, 5, and 10 years after study entry was 7.0%/3.5%, 19.9%/9.7%, and 23.9%/11.3% for CHF/ATE, and 6.7%, 22.8%, and 28.3% for cardiovascular death, respectively. There were no statistically significant differences between HOCM compared with HCM for cardiovascular morbidity or mortality, time from diagnosis to development of morbidity, or cardiovascular survival. Cats that developed cardiovascular morbidity had short survival (mean ± standard deviation, 1.3 ± 1.7 years). Overall, prolonged longevity was recorded in a minority of preclinical HCM/HOCM cats with 10% reaching 9-15 years.CONCLUSIONS AND CLINICAL IMPORTANCE: Preclinical HCM/HOCM is a global health problem of cats that carries substantial risk for CHF, ATE, and cardiovascular death. This finding underscores the need to identify therapies and monitoring strategies that decrease morbidity and mortality.
Databáze: OpenAIRE
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