Long-term treatment with theophylline reduces neutrophils, interleukin-8 and tumor necrosis factor-α in the sputum of patients with chronic obstructive pulmonary disease
| Autor: | Hirotoshi Iiboshi, Arisa Sano, Jun-ichi Ashitani, Nobuhiro Matsumoto, Masamitsu Nakazato, Shigeki Katoh, Hiroshi Mukae |
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| Rok vydání: | 2007 |
| Předmět: |
Lipopolysaccharides
Male Pulmonary and Respiratory Medicine Spirometry medicine.medical_specialty Time Factors Neutrophils Phosphodiesterase Inhibitors medicine.drug_class Administration Oral Severity of Illness Index Gastroenterology Drug Administration Schedule Cell Line Proinflammatory cytokine Pulmonary Disease Chronic Obstructive FEV1/FVC ratio Theophylline Forced Expiratory Volume Bronchodilator Internal medicine medicine Humans Pharmacology (medical) Aged COPD medicine.diagnostic_test Tumor Necrosis Factor-alpha business.industry Interleukin-8 Biochemistry (medical) Sputum Interleukin medicine.disease Bronchodilator Agents Immunology Female medicine.symptom business medicine.drug |
| Zdroj: | Pulmonary Pharmacology & Therapeutics. 20:46-51 |
| ISSN: | 1094-5539 |
| Popis: | Background The non-selective phosphodiesterase inhibitor theophylline has bronchodilator/anti-inflammatory properties and is widely used in the treatment of airways diseases. We determined the effect of long-term theophylline treatment on airway inflammation in patients with chronic obstructive pulmonary disease (COPD). Populations and methods Seventeen stable COPD patients were enrolled in the 12-month study. Theophylline was administered at 400 mg/day. We studied changes in symptoms, spirometry, sputum volume, and sputum inflammatory cytokines levels. We also examined the effects of theophylline on the release of inflammatory cytokines in vitro by measuring interleukin (IL)-8 and tumor necrosis factor (TNF)- α levels from lipopolysaccharide (LPS)-stimulated neutrophils and THP-1 cells. Results Forced vital capacity was increased and sputum IL-8 levels decreased after 4 weeks of theophylline treatment. After 6 months of theophylline treatment, forced expiratory volume in 1 s was increased, and neutrophils counts and TNF-α levels in sputum were reduced. Levels of IL-8 and TNF-α released by LPS-stimulated THP-1 cells were reduced by treatment with theophylline at 10 μg/ml. In contrast, IL-8 levels released by LPS-stimulated neutrophils were reduced by treatment with theophylline at 100 μg/ml. Conclusion Our clinical study of small population showed that long-term treatment with theophylline seems to reduce airway inflammation in stable COPD patients. |
| Databáze: | OpenAIRE |
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